346700-32-1Relevant articles and documents
Target-directed enediynes: Designed estramycins
Jones,Hynd,Wright,Purohit,Plourde II,Huber,Mathews,Li,Kilgore,Bubley,Yancisin,Brown
, p. 3688 - 3695 (2007/10/03)
The goal of selective targeting of enediyne cytotoxins has been investigated using estrogenic delivery vehicles. A series of estrogen-enediyne conjugates were assembled, and affinity for human estrogen receptor [hERα] was determined. The most promising candidate induced receptor degradation following Bergman cycloaromatization and caused inhibition of estrogen-induced transcription in T47-D human breast cancer cells.