34810-67-8

Basic information

• Product Name: 2-(1H-PYRAZOL-3-YL)PHENOL
• Synonyms: 2-(1H-PYRAZOL-3-YL)PHENOL;3-(2-HYDROXYPHENYL)PYRAZOLE;BUTTPARK 74\09-20;o-(1H-pyrazol-3-yl)phenol;3-(2-Hydroxyphenyl)-1H-pyrazole;2-(1H-Pyrazol-3-yl)pheno;2-(Pyrazol-5-yl)phenol;2-(1H-Pyrazol-3-yl)phenol
• CAS NO: 34810-67-8
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• EINECS: 252-222-4
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 34810-67-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 90-94 °C(lit.)
• Boiling Point: 381.028 °C at 760 mmHg
• Flash Point: 184.239 °C
• Appearance: /
• Density: 1.285 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(1H-PYRAZOL-3-YL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-PYRAZOL-3-YL)PHENOL(34810-67-8)
• EPA Substance Registry System: 2-(1H-PYRAZOL-3-YL)PHENOL(34810-67-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 34810-67-8(Hazardous Substances Data)

Usage

Description

2-(1H-Pyrazol-3-yl)phenol is an organic compound that serves as a valuable building block in the field of chemical synthesis. It is characterized by its unique molecular structure, which features a phenol group connected to a pyrazol ring. This structure endows the compound with specific chemical properties that make it a versatile and useful component in various synthetic applications.

Uses

Used in Chemical Synthesis:
2-(1H-Pyrazol-3-yl)phenol is used as a synthetic building block for the creation of more complex organic molecules. Its unique structure allows for a wide range of chemical reactions, making it a valuable starting material for the synthesis of various compounds with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(1H-Pyrazol-3-yl)phenol is used as a key intermediate in the development of new drugs. Its chemical properties enable it to be modified and functionalized to create novel drug candidates with potential therapeutic applications.
Used in Material Science:
2-(1H-Pyrazol-3-yl)phenol is also utilized in the field of material science, where it can be used to develop new materials with specific properties. Its unique molecular structure allows for the creation of materials with tailored characteristics, such as improved stability, reactivity, or selectivity.
Used in Research and Development:
As an organic building block, 2-(1H-Pyrazol-3-yl)phenol is extensively used in research and development laboratories. It serves as a starting point for exploring new chemical reactions, understanding reaction mechanisms, and discovering new synthetic pathways.

InChI:InChI=1/C9H8N2O/c12-9-4-2-1-3-7(9)8-5-6-10-11-8/h1-6,12H,(H,10,11)

Upstream product

• 491-38-3 1-benzopyran-4(4H)-one 
• 6005-15-8 thiochromone 
• 14386-66-4 2-(formylacetyl)phenol 
• 79-19-6 thiosemicarbazide 
• 186581-53-3 diazomethane 
• 135119-62-9 chlorhydrate de 3-(N,N-diethylaminomethyl)chromone 
• 118450-15-0 3-(2-hydroxyphenyl)-1-thiocarbamyl-5-thiosemicarbazide-2-pyrazoline 
• 170470-63-0 3-(2-hydroxyphenyl)-1,3-(bis-diphenylphosphorohydrazono)propane 
• 170470-64-1 2-diphenylphosphorohydrazino-4-diphenylphosphorohydrazono-2,3-dihydro-4H-1-benzo-pyran 
• 1776-08-5 (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 70450-82-7 3-(α-hydroxy)methylenebenzofuran-2(3H)-one 
• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 
• 16146-63-7 8-hydroxy-chromen-4-one 

Downstream Products

• 1214278-50-8 (BrC₆H₄Sb)4O₄(N₂C₃H₂C₆H₄O)4 
• 123532-18-3 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole 
• 1313202-46-8 (PhBPhPz)2 
• 1448245-79-1 C₁₂H₁₅N₃O₃S 
• 1448245-78-0 C₁₄H₁₂N₂O 
• 1616059-75-6 ethyl 2-(2-(1H-pyrazol-3-yl)phenoxy)acetate 
• 1616075-16-1 2-(2-(1H-pyrazol-3-yl)phenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide 

Relevant articles and documents

Highly efficient blue solid emitters and tautomerization-induced ON/OFF fluorescence switching based on structurally simple 3(5)-phenol-1: H -pyrazoles

3(5)-Phenyl-1H-pyrazoles are employed in this study to develop highly efficient organic crystalline solids with deep-blue ESIPT fluorescence as well as provide novel experimental insight into the mechanism of ESIPT fluorescence and generate an intriguing

Reusable manganese compounds containing pyrazole-based ligands for olefin epoxidation reactions

We describe the synthesis of new manganese(ii) and manganese(iii) complexes containing the bidentate ligands 2-(3-pyrazolyl)pyridine, pypz-H, and 3(5)-(2-hydroxyphenyl)pyrazole, HOphpz-H, with formula [MnX2(pypz-H)2] (X = Cl-, 1, CF3SO3-, 2, OAc-, 3 or NO3- (4)), [MnCl2(pypz-H)(H2O)2], 5, or [MnCl(Ophpz-H)2], 6. All the complexes have been characterized through analytical, spectroscopic and electrochemical techniques. Single X-ray structure analysis revealed a six-coordinated Mn(ii) ion in complexes 1-5, and a five-coordinated Mn(iii) ion in complex 6. Compound 5 is the first co-crystal of Mn(ii) containing Cl and H2O ligands together with bidentate nitrogen ligands. The catalytic activity of complexes 1-6 has been tested with regard to the epoxidation of styrene and, in the case of 1, 5 and 6, other alkenes have been epoxidized using peracetic acid as oxidant in different media, among which glycerol, a green solvent never used in epoxidation reactions using peracetic acid as oxidant. The catalysts show moderate to high conversions and selectivities towards the corresponding epoxides. For complexes 1, 5 and 6, a certain degree of cis → trans isomerization is observed in the case of cis-β-methylstyrene. These observations have been explained through computational calculations. The reutilization of catalysts 1 and 6 for the epoxidation of alkenes has been evaluated in [bmim]:acetonitrile mixture (bmim = 1-butyl-3-methylimidazolium), allowing the effective recyclability of the catalytic system and keeping high conversion and selectivity values up to 12 successive runs, in all cases.

Dibenzo[ b, f ]pyrazolo[1,5-d ][1,4]oxazepines: Facile construction of a rare heterocyclic system via tandem aromatic nucleophilic substitution-smiles rearrangement-denitrocyclization

Condensation of 2-(1H-pyrazol-5-yl)phenols with 1-chloro-2-nitrobenzenes under basic conditions in N,N-dimethylformamide results in a tandem, atom-economical, aromatic nucleophilic substitution-Smiles rearrangement- denitrocyclization process to provide pyrazolo-fused dibenzo[b,f][1,4]oxazepines as a single regioisomer. Georg Thieme Verlag Stuttgart · New York.