3495-46-3

Basic information

• Product Name: 1-Methyl-1-ethyl-1-propanamine
• Synonyms: 1-Methyl-1-ethyl-1-propanamine;(1-ethyl-1-methylpropyl)amine(SALTDATA: HCl);1-Ethyl-1-methylpropylamine;(1-ethyl-1-methylpropyl)amine hydrochloride;MFCD18785612;3-methylpentan-3-amine hydrochloride
• CAS NO: 3495-46-3
• Molecular Formula: C₆H₁₅N
• Molecular Weight: 101.19
• Mol File: 3495-46-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: -40.7°C (estimate)
• Boiling Point: 119.64°C (estimate)
• Appearance: /
• Density: 0.759
• Refractive Index: 1.4100
• PKA: 10.80±0.25(Predicted)
• CAS DataBase Reference: 1-Methyl-1-ethyl-1-propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1-ethyl-1-propanamine(3495-46-3)
• EPA Substance Registry System: 1-Methyl-1-ethyl-1-propanamine(3495-46-3)

Safety Data

• Hazardous Substances Data: 3495-46-3(Hazardous Substances Data)

Usage

Type of compound

Aliphatic amine

Structure

Branched chain

Physical state

Colorless, flammable liquid

Usage

Intermediate in the production of pharmaceuticals, pesticides, and other organic compounds

Reactions

Alkylation, acylation, and condensation

Synthesis

Used in the synthesis of various organic substances

Industrial applications

Ingredient in the production of surfactants, corrosion inhibitors, and other specialty chemicals

Safety precautions

Hazardous if not used properly

Upstream product

• 18369-96-5 3-amino-3-methylpentyne 
• 74253-97-7 1-ethyl-1-methyl-allylamine 
• 19889-37-3 2-methyl-2-ethylbutanoic acid 
• 51655-29-9 N-(1-ethyl-1-methyl-propyl)-acetamide 
• 55108-30-0 (1-ethyl-1-methyl-propyl)-urea 
• 118132-89-1 (1-Ethyl-1-methyl-propyl)-phosphoramidic acid diethyl ester 
• 906075-12-5 1-ethyl-1-methylpropylformamide 
• 64-17-5 ethanol 
• 77-74-7 3-methylpentan-3-ol 
• 118132-79-9 3-azido-3-methylpentane 
• 118132-83-5 1-Ethyl-1-methyl-propyl-phosphorimidic acid triethyl ester 

Downstream Products

• 67331-28-6 1-(2,6-Di-sec-butyl-phenyl)-3-(1-ethyl-1-methyl-propyl)-thiourea 
• 67330-76-1 1-(2,6-Diethyl-4-methyl-phenyl)-3-(1-ethyl-1-methyl-propyl)-thiourea 
• 67331-04-8 1-(2,6-Diisopropyl-phenyl)-3-(1-ethyl-1-methyl-propyl)-thiourea 
• 134168-88-0 N-(3,5-dichlorophenyl)-N'-(1-ethyl-1-methylpropyl)thiourea 
• 134169-03-2 N-(3,5-dichlorophenyl)-N'-(1-ethyl-1-methylpropyl)carbodiimide 

Relevant articles and documents

Carbon Dioxide as a Directing Group for C-H Functionalization Reactions Involving Lewis Basic Amines, Alcohols, Thiols, and Phosphines for the Synthesis of Compounds

Methods of synthesizing compounds using CO2 as a directing group for C—H functionalization, and compounds made thereby, are described.

cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: Synthesis and in vitro, in vivo, and x-ray crystallographic characterization

Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes in animal models and in human subjects. A novel series of cis-2,5-dicyanopyrrolidine α-amino amides were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of type 2 diabetes. 1-({[1-(Hydroxymethyl)cyclopentyl]amino}-acetyl)pyrrolidine-2,5-cis- dicarbonitrile (1c) is an achiral, slow-binding (time-dependent) inhibitor of DPP-IV that is selective for DPP-IV over other DPP isozymes and proline specific serine proteases, and which has oral bioavailability in preclinical species and in vivo efficacy in animal models. The mode of binding of the cis-2,5-dicyanopyrrolidine moiety was determined by X-ray crystallography. The hydrochloride salt of 1c was further profiled for development as a potential new treatment for type 2 diabetes.

Biologically selective potassium channel openers having 1,1- diethylpropyl group

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.