34966-97-7

Basic information

• Product Name: 1-(isothiocyanatomethyl)-2,4-dimethoxy benzene
• Synonyms: 1-(isothiocyanatomethyl)-2,4-dimethoxy benzene
• CAS NO: 34966-97-7
• Molecular Weight: 209.269
• Mol File: 34966-97-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(isothiocyanatomethyl)-2,4-dimethoxy benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(isothiocyanatomethyl)-2,4-dimethoxy benzene(34966-97-7)
• EPA Substance Registry System: 1-(isothiocyanatomethyl)-2,4-dimethoxy benzene(34966-97-7)

Safety Data

• Hazardous Substances Data: 34966-97-7(Hazardous Substances Data)

Upstream product

• 463-71-8 thiophosgene 
• 20781-20-8 2,4-Dimethoxybenzylamine 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 75-15-0 carbon disulfide 

Downstream Products

• 57661-20-8 1-(2,4-dimethoxybenzyl)-3-hydroxythiourea 
• 1427500-75-1 N-2-amino-6-bromo-5-chloro-(2,4-dimethoxybenzyl)thiazolo[4,5-b]pyrazine 

Relevant articles and documents

Synthesis of N hydroxythiourea

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HETEROCYCLIC COMPOUNDS AS HIV PROTEASE INHIBITORS

The present invention is directed to compounds of Formula I, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Construction of Druglike 2-Amido Benzo[ d]imidazole Analogues via Desulfurative Cyclization of Thiourea Intermediate Resin on Solid-Phase

A 2-amido benzo[d]imidazole library has been constructed by solid-phase synthesis. The key step of this solid-phase synthesis involves the preparation of polymer-bound 2-amino benzo[d]imidazole resin through desulfurative cyclization of thiourea resin using 2-chloro-1,3-dimethylimidazolinium chloride and N,N-diisopropylethylamine in dichloromethane (DCM), and the resin is then functionalized by acylation at the 2-amine position to afford 2-amidobenzo[d]imidazole resin. In the case of 2-amidobenzo[d]imidazole resin having a p-I or m-NO2, the resin was further functionalized by Suzuki/Sonogashira-coupling (p-I) and reduction to the primary amine (m-NO2) followed by acylation. Finally, the functionalized 2-amido-benzo[d]imidazole resin was cleaved from the polymer support by treatment with a cocktail of trifluoroacetic acid and DCM. As a result, we obtained 2-amidobenzo[d]imidazole analogues in high yield and good purities.