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350-28-7

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350-28-7 Usage

Description

3-Fluoro-4-methylbenzoic acid is a white to light yellow crystal powder that is a derivative of benzoic acid with a fluorine atom at the 3rd position and a methyl group at the 4th position. It is a synthetically useful building block in the pharmaceutical and chemical industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-methylbenzoic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. It is particularly utilized in the development of cyclooxygenase selective and orally active anti-inflammatory agents, which are essential for treating conditions like pain, fever, and inflammation.
Additionally, 3-Fluoro-4-methylbenzoic acid is used as a starting material for the preparation of benzamide derivatives, which serve as Bcr-Abl kinase inhibitors. These inhibitors are crucial in the treatment of certain types of cancers, such as chronic myeloid leukemia (CML), by targeting the specific enzyme responsible for the uncontrolled cell growth.
Used in Chemical Industry:
In the chemical industry, 3-Fluoro-4-methylbenzoic acid is employed as a versatile building block for the synthesis of various organic compounds, including agrochemicals, dyes, and specialty chemicals. Its unique fluorinated and methylated structure allows for the creation of a wide range of products with diverse applications.

Check Digit Verification of cas no

The CAS Registry Mumber 350-28-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 350-28:
(5*3)+(4*5)+(3*0)+(2*2)+(1*8)=47
47 % 10 = 7
So 350-28-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FO2/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,1H3,(H,10,11)/p-1

350-28-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Fluoro-4-methylbenzoic acid

1.2 Other means of identification

Product number -
Other names 3-Fluoro-p-toluic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:350-28-7 SDS

350-28-7Relevant articles and documents

Method for preparing aromatic carboxylic acid compound

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Paragraph 0085-0086; 0109-0111; 0176, (2020/02/14)

The invention discloses a method for preparing an aromatic carboxylic acid compound. The method comprises the following steps: 1) heating carbon dioxide and hydrosilane in the presence of a copper catalyst in a reaction medium A; and 2) adding a reaction medium B, aryl halide, a palladium catalyst and a base to the reaction mixture in the step 1), sealing the reaction system, and performing a heating reaction. The method has the advantages that raw materials are simple and easy to obtain, the raw materials are cheap and stable, the catalyst is common, easy to obtain and stable, the reaction conditionsaremild, the aftertreatment is simple, the yield is high, and the like.

Ligand-Free Palladium-Catalyzed Hydroxycarbonylation of Aryl Halides under Ambient Conditions: Synthesis of Aromatic Carboxylic Acids and Aromatic Esters

Han, Wei,Jin, Fengli,Zhou, Qing

, p. 1861 - 1868 (2015/06/30)

Aryl halides were readily converted into their corresponding aromatic carboxylic acids in high yields with high selectivity by ligand-free palladium-catalyzed hydroxycarbonylation at room temperature and atmospheric pressure. The new method is operationally simple and scalable. In addition, aromatic esters were easily synthesized through one-pot hydroxycarbonylation/alkylation with alkyl halides.

Syntheses of 4-methoxymethylbenzyl permethrinates containing fluorine and their insecticidal activity

Zou, Xinzhuo,Qiu, Zongxing

, p. 173 - 179 (2007/10/03)

In order to investigate the relationship between the position of fluorine atom and insecticidal activity about 4-methoxymethylbenzyl permethrinates containing fluorine, 2 and 3-fluoro-4-methoxymethylbenzyl (±)-cis-permethrinate were synthesized. Their insecticidal activities were tested and the fluorine effect of title compounds was discussed.

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