350014-20-9Relevant articles and documents
Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues
Li, James J.,Wang, Haixia,Qu, Fucheng,Musial, Christa,Tino, Joseph A.,Robl, Jeffrey A.,Slusarchyk, Dorothy,Golla, Rajasree,Seethala, Ramakrishna,Dickinson, Kenneth,Giupponi, Leah,Grover, Gary,Sleph, Paul,Flynn, Neil,Murphy, Brian J.,Gordon, David,Kung, Melissa,Stoffel, Robert
, p. 1799 - 1802 (2005)
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
Lactam derivatives as antiarrhythmic agents
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, (2008/06/13)
Lactam derivatives of the formula where X is —C(═O)NR3′—, —NR3′C(═O)—, —C(═NCN)NR3′—, —NR3′C(═NCN)—, —CH2NR3′—, —CH(alkyl)NR3′—, —CH(COOalkyl)NR3′—, —CH(CH2