373633-77-3

Basic information

• Product Name: 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester
• Synonyms: 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester
• CAS NO: 373633-77-3
• Molecular Weight: 509.689
• Mol File: 373633-77-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester(373633-77-3)
• EPA Substance Registry System: 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester(373633-77-3)

Safety Data

• Hazardous Substances Data: 373633-77-3(Hazardous Substances Data)

Upstream product

• 121-05-1 N',N'-diisopropyl-ethane-1,2-diamine 
• 373638-25-6 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester 
• 588-05-6 m-tyramine 
• 91523-50-1 rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 350014-18-5 1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester 
• 350014-19-6 methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate 
• 350014-20-9 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 38449-59-1 2-(3-hydroxyphenyl)ethylamine hydrobromide 
• 1068562-72-0 C₂₁H₂₉NO₇ 

Downstream Products

• 373638-23-4 1-[[[(R)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester 
• 373633-80-8 1-[[[(S)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester 
• 373633-79-5 1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate 
• 373638-29-0 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide 

Relevant articles and documents

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.

Tetrahydroisoquinoline analogs useful as growth hormone secretagogues

Tetrahydroisoquinoline analogs are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The tetrahdroisoquinoline analogs thereof have the structure wherein R1, R2, R3, R3a, X1, X2, X3, X4, m and n are as described herein.