35090-64-3Relevant articles and documents
Novel titanium(IV) complexes stabilized by 2-hydroxybenzyl alcohol derivatives as catalysts for UHMWPE production
Tuskaev, Vladislav A.,Gagieva, Svetlana C.,Kurmaev, Dmitry A.,Zubkevich, Sergey V.,Kolosov, Nikolay A.,Golubev, Evgenii K.,Nikiforova, Galina G.,Khrustalev, Victor N.,Bulychev, Boris M.
, p. 266 - 272 (2018)
A series of titanium (IV) complexes (2, 5-7) stabilized by a substituted 2-hydroxybenzyl alcohols (1, 4) – were synthesized. Structures of complexes 6-7 were determined by X-ray diffraction. Titanium atom in the tetrameric complex 6 has an octahedral envi
Approach to Merosesquiterpenes via Lewis Acid Catalyzed Nazarov-Type Cyclization: Total Synthesis of Akaol A
Kakde, Badrinath N.,Kumar, Nivesh,Mondal, Pradip Kumar,Bisai, Alakesh
supporting information, p. 1752 - 1755 (2016/05/19)
A Lewis acid catalyzed Nazarov-type cyclization of arylvinylcarbinol has been developed for the asymmetric synthesis of carbotetracyclic core of merosesquiterpenes. The reaction works only in the presence of 2 mol % of Sn(OTf)2 and Bi(OTf)3 in dichloroethane under elevated temperature. The methodology offers the synthesis of a variety of enantioenriched arylvinylcarbinols from commercially available (3aR)-sclareolide 9 in six steps with an eventual concise total synthesis of marine sesquiterpene quinol, akaol A (1a).
Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective α2C-adrenergic receptor antagonists
Hagihara, Koji,Kashima, Hajime,Iida, Kyoichiro,Enokizono, Junichi,Uchida, Shin-ichi,Nonaka, Hiromi,Kurokawa, Masako,Shimada, Junichi
, p. 1616 - 1621 (2007/10/03)
The synthesis of a series of 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl-2-arylbenzofuran and 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran-2-carboxamide derivatives as novel α2C-adrenergic receptor antagonists are described. Their affinity at three different human α2-adrenergic receptors is reported, and some of these compounds exhibited high affinity for the α2C-adrenergic receptor with high subtype selectivity. Among them, compound 10e has been found to show the anti-l-dopa-induced dyskinetic activity in marmosets. The structure-activity relationship of these compounds is also discussed.