515814-05-8

Basic information

• Product Name: 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran
• Synonyms: 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran
• CAS NO: 515814-05-8
• Molecular Weight: 439.305
• Mol File: 515814-05-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran(515814-05-8)
• EPA Substance Registry System: 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran(515814-05-8)

Safety Data

• Hazardous Substances Data: 515814-05-8(Hazardous Substances Data)

Upstream product

• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 1486-52-8 3-methoxy-4-benzyloxybenzoyl chloride 
• 35090-64-3 2-hydroxy-3-methoxy-5-bromobenzyl alcohol 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 121-33-5 vanillin 
• 100-44-7 benzyl chloride 
• 1233720-57-4 2-[4-(benzyloxy)-3-methoxystyryl]-4-bromo-6-methoxyphenol 
• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 
• 56897-51-9 5-bromo-7-methoxy-2-nitrobenzofuran 
• 515814-03-6 5-bromo-7-methoxy-2-bromobenzofuran 

Downstream Products

• 144735-56-8 5-((2-methoxycarbonyl)ethyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 
• 144735-57-9 2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofurane 
• 213970-70-8 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran 
• 144735-55-7 5-(2-(methoxycarbonyl)trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-(benzyloxy)phenyl)benzofuran 
• 1254219-34-5 2-(4-benzyloxy-3-methoxyphenyl)-7-methoxy-5-(1-propenyl)benzofuran 
• 515814-08-1 5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran 
• 515814-07-0 (E)-2-(4-benzyloxy-3-methoxyphenyl)-5-(3-acetoxypropenyl)-7-methoxybenzofuran 
• 213970-71-9 2-(p-hydroxy-m-methoxyphenyl)-7-methoxy-5-(carbethoxy-1-propen-1-yl)benzo[b]furan 
• 156398-61-7 (E)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxyprop-1-enyl)-7-methoxybenzofuran 
• 135040-88-9 2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxybenzofuran 
• 515814-06-9 (E)-2-(4-benzyloxy-3-methoxyphenyl)-5-(3-hydroxypropenyl)-7-methoxybenzofuran 

Relevant articles and documents

An alternate method for the synthesis of 2-aryl/alkyl-5-bromo-7-methoxy benzofurans; application to the synthesis of Egonol, Homoegonol, and analogs via Heck reaction

We herein report the general, versatile, and convenient method for the synthesis of 2-arly/alkyl-5-bromo-7-methoxy benzofurans from easily available o-Vanillin in five steps. These benzofurans was successfully converted into biological active natural products Egonol, Homoegonol, and analogous on applying Heck reaction using ethyl/methyl acrylate in the presence of palladium catalyst.

Total synthesis of ailanthoidol, egonol, and related analogues

Efficient and general synthetic protocols were developed for the total synthesis of ailanthoidol, egonol, and some related analogues. The key transformations describe here involve a two-step construction of the benzofuran and a Sonogashira coupling, and proved to be convenient and effective, starting from readily available reagents.

Total synthesis of ailanthoidol and precursor XH14 by stille coupling

Ailanthoidol 1, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only six steps in 48% overall yield from commercially available 5-bromo-2-hydroxy-3-methoxybenzaldehyde. The key transformations in the