35173-74-1Relevant articles and documents
Lewis acid-catalyzed reactions in protic media. Lanthanide-catalyzed reactions of indoles with aldehydes or ketones
Chen, Depu,Yu, Libing,Wang, Peng George
, p. 4467 - 4470 (1996)
Lanthanide triflates were found to be effective catalysts for reactions of indoles with aldehydes or ketones in aqueous solution.
Highly enantioselective Friedel-Crafts reaction of indoles with imines by a chiral phosphoric acid
Kang, Qiang,Zhao, Zhuo-An,You, Shu-Li
, p. 1484 - 1485 (2007)
Highly enantioselective Friedel-Crafts reactions of indoles with imines catalyzed by a chiral phosphoric acid are developed, affording the 3-indolyl methanamine derivatives with up to >99% ee for a wide range of substrates. Copyright
Novel method for synthesis of unsymmetrical bis(indolyl)alkanes catalyzed by ceric ammonium nitrate (CAN) under ultrasonic irradiation
Zeng, Xiao-Fei,Ji, Shun-Jun,Wang, Shun-Yi
, p. 10235 - 10241 (2005)
The reaction of indole with (1H-indol-3-yl)(alkyl) methanol was catalyzed efficiently by ceric ammonium nitrate under ultrasonic irradiation to afford the unsymmetrical bis(indolyl)alkane in good to excellent yields.
Solvent-free indoles addition to carbonyl compounds promoted by CeCl 3·7H2O-NaI-SiO2: An efficient method for the synthesis of streptindole
Bartoli, Giuseppe,Bosco, Marcella,Foglia, Gioia,Giuliani, Arianna,Marcantoni, Enrico,Sambri, Letizia
, p. 895 - 900 (2004)
Efficient electrophilic substitution reactions of indoles with various carbonyl compounds proceed easily in solvent-free conditions using CeCl 3·7H2O-NaI-SiO2. system promoter, to afford the corresponding bis(1H-indol-3-yl
Bis-indolylation of aldehydes and ketones using silica-supported FeCl3: Molecular docking studies of bisindoles by targeting SARS-CoV-2 main protease binding sites
Deb, Barnali,Debnath, Sudhan,Chakraborty, Ankita,Majumdar, Swapan
, p. 30827 - 30839 (2021/11/19)
We report herein an operationally simple, efficient and versatile procedure for the synthesis of bis-indolylmethanes via the reaction of indoles with aldehydes or ketones in the presence of silica-supported ferric chloride under grindstone conditions. The prepared supported catalyst was characterized by SEM and EDX spectroscopy. The present protocol has several advantages such as shorter reaction time, high yield, avoidance of using harmful organic solvents during the reaction and tolerance of a wide range of functional groups. Molecular docking studies targeted toward the binding site of SARS-CoV-2 main protease (3CLpro or Mpro) enzymes were investigated with the synthesized bis-indoles. Our study revealed that some of the synthesized compounds have potentiality to inhibit the SARS-CoV-2 Mpro enzyme by interacting with key amino acid residues of the active sites via hydrophobic as well as hydrogen bonding interactions.
Magnetically recyclable CuFe2O4 catalyst for efficient synthesis of bis(indolyl)methanes using indoles and alcohols under mild condition
Bui, Hoang Yen,Dang, Tuan Thanh,Ha, Minh-Tuan,Hung, Tran Quang,Nguyen, Ngoc-Khanh,Nguyen, Van Tuyen,Tran, Bich Ngoc,Trinh, Quang Thang,Vu, Xuan Hoan
, (2020/11/30)
Bis(3-indolyl)methanes (BIM) are highly valuable and appear in the core structure of many natural products and pharmacologically active compounds (anticancer, anti-inflammatory, antiobesity, antimetastatic, antimicrobial, etc.). Herein, we have disclosed