35294-37-2

Basic information

• Product Name: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE
• Synonyms: 1-[4-(2-THIENYL)PHENYL]ETHANONE;1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE;AKOS BAR-0220;4-(2-THIENYL)ACETOPHENONE;1-(4-THIEN-2-YLPHENYL)ETHANONE;1-[4-(thiophen-2-yl)phenyl]ethan-1-one
• CAS NO: 35294-37-2
• Molecular Formula: C₁₂H₁₀OS
• Molecular Weight: 202.27
• Mol File: 35294-37-2.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 323 °C at 760 mmHg
• Flash Point: 149.1 °C
• Appearance: /
• Density: 1.151 g/cm³
• CAS DataBase Reference: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE(35294-37-2)
• EPA Substance Registry System: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE(35294-37-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 35294-37-2(Hazardous Substances Data)

Usage

Description

1-(4-thiophen-2-yl-phenyl)-ethanone, also known as thiophene-2-phenyl-1-ethanone, is an organic compound with the molecular formula C14H12OS. It is a ketone with a thiophene ring and a phenyl ring attached to an ethanone group. This chemical is characterized by its strong odor and is a flammable liquid, necessitating proper handling and storage. Due to its potential health hazards, it is important to follow safety protocols when working with 1-(4-thiophen-2-yl-phenyl)-ethanone.

Uses

Used in Pharmaceutical Industry:
1-(4-thiophen-2-yl-phenyl)-ethanone is used as a building block for the synthesis of pharmaceuticals. It plays a crucial role in the development of various drugs due to its unique chemical structure and properties.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-thiophen-2-yl-phenyl)-ethanone is utilized as a precursor for the synthesis of agrochemicals. Its chemical properties make it a valuable component in the creation of pesticides and other agricultural products.
Used in Dye and Pigment Production:
1-(4-thiophen-2-yl-phenyl)-ethanone is used in the production of dyes and pigments. Its chemical composition contributes to the color and stability of these products, making it an essential component in this industry.
Used as a Flavoring Agent in the Food Industry:
1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE is also used as a flavoring agent in the food industry. Its unique properties allow it to impart specific flavors and aromas to various food products, enhancing their overall taste and appeal.

Upstream product

• 188290-36-0 thiophene 
• 99-90-1 para-bromoacetophenone 
• 5980-89-2 di-[2]thienyl-mercury 
• 13329-40-3 4-Iodoacetophenone 
• 127118-94-9 ethyl(difluoro)(2-thienyl)silane 
• 6165-68-0 thiophene boronic acid 
• 99-91-2 para-chloroacetophenone 
• 1003-09-4 2-bromothiophene 
• 149104-90-5 4-acetylphenylboronic acid 
• 124733-28-4 1,1,3,3-tetramethyl-1,3-bis(2'-thienyl)disiloxane 
• 3437-95-4 2-Iodothiophene 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 438569-05-2 1-(4-(triethoxysilyl)phenyl)ethanone 
• 17984-89-3 triethoxy(thiophen-2-yl)silane 

Downstream Products

• 128746-80-5 2-bromo-1-[4-(2-thienyl)phenyl]-1-ethanone 
• 1060772-73-7 2-bromo-5-(4-bromoacetylphenyl)thiophene 
• 1186236-78-1 piperidine-1-carboxylic acid 1-(4-thiophen-2-yl-phenyl)vinyl ester 

Relevant articles and documents

Polyglycerol as a high-loading support for boronic acids with application in solution-phase Suzuki cross-couplings

In this paper, we describe the usage of a soluble high-loading polyglycerol support for functionalized boronic acids without further linker design. The quantitatively formed polyglycerol boron esters were subsequently employed in homogeneous Suzuki cross-coupling reactions to give high yields (84-91%) of functional biaryls with minimal amounts of the Pd catalyst (0.2 mol %). In situ precipitation and ultrafiltration were used as simple and effective purification protocols. Furthermore, the reaction conditions were optimized by the choice of the solvent and the catalyst.

Polysulfide Anions as Visible Light Photoredox Catalysts for Aryl Cross-Couplings

Polysulfide anions are endowed with unique redox properties, attracting considerable attentions for their applications in alkali metals-sulfur batteries. However, the employment of these anionic species in redox catalysis for small molecule synthesis remains underdeveloped due to their moderate-poor electrochemical potential in the ground state, whereas some of them are characterized by photoabsorptions in visible spectral regions. Herein, we disclose the use of polysulfide anions as visible light photoredox catalysts for aryl cross-coupling reactions. The reaction design enables single-electron reduction of aryl halides upon the photoexcitation of tetrasulfide dianions (S42-). The resulting aryl radicals are engaged in (hetero)biaryl cross-coupling, borylation, and hydrogenation in a redox catalytic regime involving S4?-/S42- and S3?-/S32- redox couples.

Palladium-catalyzed acetylation of arylbromides

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