35504-85-9

Basic information

• Product Name: (E)-3-(4-Fluorobenzoyl)acrylic acid
• Synonyms: (E)-3-(4-Fluorobenzoyl)acrylic acid;(E)-4-(4-Fluorophenyl)-4-oxo-2-butenoic acid
• CAS NO: 35504-85-9
• Molecular Formula: C₁₀H₇FO₃
• Molecular Weight: 194.16
• Mol File: 35504-85-9.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 347.9°Cat760mmHg
• Flash Point: 164.2°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 1.97E-05mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: (E)-3-(4-Fluorobenzoyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-Fluorobenzoyl)acrylic acid(35504-85-9)
• EPA Substance Registry System: (E)-3-(4-Fluorobenzoyl)acrylic acid(35504-85-9)

Safety Data

• Hazardous Substances Data: 35504-85-9(Hazardous Substances Data)

Usage

Description

(E)-3-(4-Fluorobenzoyl)acrylic acid, also known as 4-Fluorocinnamic acid, is an organic compound with the molecular formula C10H7FO2. It is a derivative of cinnamic acid with a fluorine substituent on the benzene ring. This chemical is commonly used in organic synthesis and pharmaceutical research as an intermediate for the production of various pharmaceuticals and agrochemicals. It possesses potential biological and pharmacological activities, making it a valuable compound in medicinal chemistry. Additionally, (E)-3-(4-Fluorobenzoyl)acrylic acid has the potential to be used in the development of new drug formulations and therapies due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Research:
(E)-3-(4-Fluorobenzoyl)acrylic acid is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological and pharmacological activities.
Used in Agrochemical Production:
(E)-3-(4-Fluorobenzoyl)acrylic acid is used as an intermediate in the production of agrochemicals, contributing to the development of new compounds for agricultural applications.
Used in Medicinal Chemistry:
(E)-3-(4-Fluorobenzoyl)acrylic acid is used as a valuable compound in medicinal chemistry for its potential to be utilized in the development of new drug formulations and therapies.
Used in Organic Synthesis:
(E)-3-(4-Fluorobenzoyl)acrylic acid is used as a key component in organic synthesis, allowing for the creation of a variety of chemical compounds with diverse applications.

InChI:InChI=1/C10H7FO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-6H,(H,13,14)/b6-5+

Upstream product

• 81008-12-0 4-(4-fluorophenyl)-2-hydroxy-4-oxobutyric acid 
• 108-31-6 maleic anhydride 
• 462-06-6 fluorobenzene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 6000-59-5 glyoxalic acid monohydrate 
• 298-12-4 Glyoxilic acid 
• 75175-77-8 3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one 

Downstream Products

• 97220-74-1 2-acetylthio-3-(4-fluorobenzoyl)propionic acid 
• 181271-63-6 8-chloro-4-(4-fluoro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepine-2-carboxylic acid 
• 181271-61-4 4-(4-fluoro-phenyl)-8-methyl-2,3-dihydro-benzo[b][1,4]thiazepine-2-carboxylic acid 
• 181271-62-5 8-fluoro-4-(4-fluoro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepine-2-carboxylic acid 
• 181271-64-7 8-bromo-4-(4-fluoro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepine-2-carboxylic acid 
• 181271-60-3 4-(4-fluoro-phenyl)-8-methoxy-2,3-dihydro-benzo[b][1,4]thiazepine-2-carboxylic acid 
• 1583-50-2 2-[2-(4-fluorophenyl)-2-oxoethyl]-4H-benzo-1,4-thiazin-3-one 

Relevant articles and documents

ENHANCER OF FERTILIZATION FUNCTION OF SPERM

An object of the present invention is to provide an agent for enhancing fertilization function of a mammal sperm, which comprises a low molecular compound which can be produced relatively easily and inexpensively as an active ingredient, and a method for enhancing fertilization function of a mammal sperm and a method for preparing a mammal fertilized egg, which use a low molecular compound which can be produced relatively easily and inexpensively. An agent comprising one or more compounds selected from the group consisting of compounds of the following formula (I0), formula (II), and formula (III), and physiologically acceptable salts thereof when R3 is OH is used as an agent for enhancing fertilization function of a mammal sperm.

Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid

4-Oxobutenoic acids are useful as biologically active species and as versatile intermediates for further derivatisation. Currently, routes to their synthesis can be problematic and lack generality. Reaction conditions for the synthesis of 4-oxo-2-butenoic

Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents

A series of novel (E)-4-oxo-2-crotonamide derivatives were designed and synthesized to find potent antituberculosis agents. All the target compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv(MTB). Results reveal that 4-phenyl moiety at part A and short methyl group at part C were found to be favorable. Most of the derivatives displayed promising activity against MTB with MIC ranging from 0.125 to 4 μg/mL. Especially, compound IIIa16 was found to have the best activity with MIC of 0.125 μg/mL against MTB and with MIC in the range of 0.05–0.48 μg/mL against drug-resistant clinical MTB isolates.