3563-01-7 Usage
Originator
Aprofene,ZYF Pharm Chemical
Manufacturing Process
32 parts of α,α-diphenylpropionic acid chloride (made from diphenylpropionic
acid and thionyl chloride, B.P./12 mm 170°C) are mixed with 50 parts of
diethylaminoethanol. The mixture is heated for two hours to 150°-160°C. It is
then suspended in dilute hydrochloric acid. The solution is treated with ether.
After separation of the aqueous solution, the base is precipitated with sodium
hydroxide solution and suspended in ether.
After removal of the ether by distillation, the residue is distilled in a vacuum.
α,α-Diphenylpropionic acid β-diethylaminoethyl ester is obtained as a thick oil
by distilling under 2 mm pressure at 180°-185°C. It is readily soluble in
diluted acids.
Therapeutic Function
Spasmolytic
Check Digit Verification of cas no
The CAS Registry Mumber 3563-01-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,6 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3563-01:
(6*3)+(5*5)+(4*6)+(3*3)+(2*0)+(1*1)=77
77 % 10 = 7
So 3563-01-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3
3563-01-7Relevant articles and documents
Room Temperature Coupling of Aryldiazoacetates with Boronic Acids Enhanced by Blue Light Irradiation
da Silva, Amanda F.,Afonso, Marco A. S.,Cormanich, Rodrigo A.,Jurberg, Igor D.
, p. 5648 - 5653 (2020/04/22)
A visible-light-promoted photochemical protocol is reported for the coupling of aryldiazoacetates with boronic acids. This photochemical reaction shows great enhancement compared to the same protocol performed in the absence of light. Except for a few cases, the room temperature coupling in the dark (thermal process) generally does not work. When it does, it is likely to also involve free carbenes as key intermediates. Alternatively, photochemical reactions show a broad scope, can be performed under air and tolerate a wide variety of functional groups. Reaction-evolution monitoring, DFT calculations and control experiments have been used to evaluate the main aspects of this intricate mechanistic scenario. Biologically active molecules Adiphenine, Benactyzine and Aprophen have been prepared as examples of synthetic applications.
Structure-activity relations. I. Series of antagonists of acetylcholine and histamine at the postganglionic receptors.
Bowden,Young
, p. 225,226 (2007/10/05)
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