3564-73-6

Basic information

• Product Name: 10,11-DIHYDROCARBAMAZEPINE
• Synonyms: f)azepine-5-carboxamide,10,11-dihydro-5h-dibenz(;10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE;10,11-DIHYDROCARBAMAZEPINE;10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide;10,11-Dihydro5H-dibenzo[b,f]azepine-5-carboxamide;10,11-Dihydrocarbamazepine,99%;5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide;10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide
• CAS NO: 3564-73-6
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.28
• EINECS: 222-649-0
• Product Categories: Amines;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 3564-73-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 205-210 °C(lit.)
• Boiling Point: 394.5°Cat760mmHg
• Flash Point: 192.4°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 1.96E-06mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: Refrigerator
• Solubility: dichloromethane: soluble2.5%, clear, colorless
• PKA: 14.07±0.20(Predicted)
• Water Solubility: Soluble in dichloromethane. Insoluble in water.
• BRN: 196969
• CAS DataBase Reference: 10,11-DIHYDROCARBAMAZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 10,11-DIHYDROCARBAMAZEPINE(3564-73-6)
• EPA Substance Registry System: 10,11-DIHYDROCARBAMAZEPINE(3564-73-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-42/43
• Safety Statements: 22-24/25-45-36/37
• WGK Germany: 3
• RTECS: HN8300000
• Hazardous Substances Data: 3564-73-6(Hazardous Substances Data)

Usage

Description

10,11-Dihydrocarbamazepine is an impurity found in the dibenzazepine drug Carbamazepine, which is primarily used in the treatment of epilepsy. 10,11-DIHYDROCARBAMAZEPINE has a single-crystal structure that has been investigated, and it is known for its role as a dihydro impurity in the pharmaceutical context.

Uses

Used in Pharmaceutical Industry:
10,11-Dihydrocarbamazepine is used as an internal standard during the simultaneous determination of carbamazepine and its active metabolite in plasma by liquid chromatography. This application aids in ensuring accurate and reliable measurements of the drug and its metabolite levels in patients undergoing treatment.
Additionally, 10,11-Dihydrocarbamazepine can be used in chemiluminescence methods for the determination of carbamazepine. This method is valuable for its sensitivity and specificity in detecting and quantifying the drug in various samples, such as biological fluids or pharmaceutical formulations.

InChI:InChI=1/C15H14N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-8H,9-10H2,(H2,16,18)

Upstream product

• 33948-19-5 10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride 
• 298-46-4 carbamazepin 
• 494-19-9 9,10-dihydrodibenzazepine 
• 33948-22-0 5H-dibenz[b,f]azepine-5-carbonylchloride 

Downstream Products

• 29331-92-8 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide 
• 28721-07-5 oxcarbazepine 
• 537693-29-1 10,11-dioxo-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide 
• 298-46-4 carbamazepin 

Relevant articles and documents

Method for synthesizing carbamazepine

The invention discloses a method for synthesizing carbamazepine. The method takes iminodibenzyl and chlorobenzene as raw materials and comprises the following steps: introducing triphosgene to obtainacyl chloride, performing bromination with bromine to obtain bromide, performing ammoniation with ammonium hydroxide to obtain a crude product of the carbamazepine, and finally, refining the crude product with ethanol to obtain a finished product of the carbamazepine. The acyl chlorination, bromination and ammoniation adopt chlorobenzene as a reaction solvent to reduce consumption of other solvents; in the acyl chlorination reaction, the triphosgene replaces phosgene to solve the problems of safety and environmental protection in the process; the obtained acyl chloride is not separated and isdirectly subjected to bromination dehydrogenation and ammoniation reaction to lower the operation cost; the yield of each step of the synthesis process is 93% or higher, thereby improving the production efficiency and lowering the production cost; and the synthesis process adopts self-designed novel closed equipment to reduce the consumption of chlorobenzene and ethanol, thereby being suitable forindustrial production.

Electrochemical reduction of 5H-dibenz[b,f]azepine derivatives. Part 5: Cathodic behaviour of carbamazepine-ammonium halide addition compounds

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