494-19-9Relevant articles and documents
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Profitt,Ong
, p. 3972 (1979)
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Kinetics and thermodynamic parameters of the thermal decomposition of imipramine hydrochloride and trimipramine maleate
Abu-Eittah, Rafie H.,Kamel, Laila T.
, p. 166 - 179 (2003)
Thermal decomposition of imipramine hydrochloride and trimipramine maleate has been investigated isothermally and nonisothermally. The kinetic parameters, namely the activation energy Ea and the Arrhenius preexponential term A, were calculated. Applying the theory of activated complex to the process of decomposition one calculated ΔS≠, ΔH≠, and ΔG≠ for the reaction. The values of Ea as well as the thermodynamic functions did not vary significantly with temperature of the reaction whereas the preexponential term showed a significant dependence on the reaction temperature. Both imipramine hydrochloride and trimipramine maleate showed two main steps of decomposition. Each step proved to be a first-order reaction. The rate constant was calculated for each step, and the results were analyzed statistically.
Combined KOH/BEt3Catalyst for Selective Deaminative Hydroboration of Aromatic Carboxamides for Construction of Luminophores
Li, Jinshan,Wang, Jiali,Yang, Jianguo,Yao, Wubing,Zhong, Aiguo
supporting information, p. 8086 - 8090 (2020/11/03)
The selective catalytic C-N bond cleavage of amides into value-added amine products is a desirable but challenging transformation. Molecules containing iminodibenzyl motifs are prevalent in pharmaceutical molecules and functional materials. Here we established a combined KOH/BEt3 catalyst for deaminative hydroboration of acyl-iminodibenzyl derivatives, including nonheterocyclic carboxamides, to the corresponding amines. This novel transition-metal-free methodology was also applied to the construction of Clomipramine and luminophores.
Synthesis method of iminodibenzyl
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Paragraph 0006; 0016; 0018-0019; 0020-0027, (2020/07/02)
The invention relates to the field of drug intermediate synthesis, in particular to a synthesis method of iminodibenzyl, which mainly comprises two steps: a reduction reaction and a cyclization reaction. The yield can be improved to 88%-92% through fine control of the reduction reaction and the cyclization reaction, and the synthesis method has great industrial significance and is worthy of further popularization.