64097-61-6

Basic information

• Product Name: 2,8-bis(morpholin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
• CAS NO: 64097-61-6
• Molecular Formula: C₂₄H₃₁N₃O₂
• Molecular Weight: 393.5218
• Mol File: 64097-61-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 531.4°C at 760 mmHg
• Flash Point: 275.2°C
• Density: 1.175g/cm³
• Vapor Pressure: 2.25E-11mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 2,8-bis(morpholin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,8-bis(morpholin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine(64097-61-6)
• EPA Substance Registry System: 2,8-bis(morpholin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine(64097-61-6)

Safety Data

• Hazardous Substances Data: 64097-61-6(Hazardous Substances Data)

Usage

General Description

2,8-bis(morpholin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine is a chemical compound with the molecular formula C28H32N2O2. It is a tricyclic antidepressant that acts by blocking the reuptake of serotonin and norepinephrine in the brain, leading to an increase in their levels and ultimately improving mood and relieving symptoms of depression. 2,8-bis(morpholin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine is used in the treatment of major depressive disorder, as well as other mood disorders and anxiety disorders. It is typically administered orally and its therapeutic effects can be observed within a few weeks of starting treatment. However, it may also have potential side effects and interactions with other medications, so it should be used under the guidance of a healthcare professional.

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 494-19-9 9,10-dihydrodibenzazepine 

Relevant articles and documents

Aminomethylation de l'homoacridane, de l'iminodibenzyle et de l'iminostilbene

The aminomethylation of 6,11-dihydro-5H-dibenzoazepine (HA), 10,11-dihydro-5H-dibenzoazepine (IDB) and dibenzoazepine (ISB) was studied in order to evaluate modifications of antidepressive activities of these tricyclic structures.By reaction with formalin and a secondary amine in ethanol medium acidified by means of acetic acid, homoacridane (HA) leads to a monosubstitution product on carbone 2 (yield 50percent).Iminodibenzyl (IDB) and iminostilbene (ISB) also give monoaminomethylation products in analogous position (yields are respectively 74 and 59percent).In each case, the optimum amount of acetic acid has been determined.If acetic acid is used as the solvent, diaminomethylation is observed in positions 2 and 8 (yiels are 74percent for IDB and 59percent for ISB).Structures of the isolated products have been studied by IR and 1H nmr.The postulated mechanism of aromatic electrophilic substitution is discussed with respect to various factors: differences in basicities of heterocyclic amines; electronic structures and nitrogen activation of aromatic tricyclic systems; influence of amount of acetic acid on salification equilibria.