74074-21-8Relevant articles and documents
Influence of the alkyl side chain length on the room-temperature phosphorescence of organic copolymers
Lin, Xiaohan,Ma, Liangwei,Ma, Xiang,Wang, Qiaochun,Xu, Qingyang
supporting information, (2022/02/07)
Pure organic room-temperature phosphorescence (RTP) materials have attracted wide attention owing to their excellent luminescent properties and great potential in various applications. In this work, iminostilbene and its analogues are applied to realize RTP emission by copolymerizing with acrylamide. It can be concluded that the growth of alkane chain in monomers can enhance the lifetime and photoluminescence quantum yield of RTP emission, and polymers with the larger conjugated structure of the monomer show a longer RTP emission wavelength. This work provides a series of new pure organic RTP materials and might provide new thoughts for designing more advanced and superior RTP materials.
In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine
Taleli, Lebusetsa,De Kock, Carmen,Smith, Peter J.,Pelly, Stephen C.,Blackie, Margaret A.L.,Van Otterlo, Willem A.L.
, p. A4163 - A4171 (2015/08/03)
The synthesis and in vitro evaluation of novel triazole-linked chloroquinoline derivatives as potential antiplasmodial agents against Plasmodium falciparum is reported. The 15 synthesized target compounds were obtained by means of a copper(I)-mediated click reaction between a variety of 1,2- and 1,3-azidoamines and 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine in moderate to good yields (53-85%). The compounds were screened for antiplasmodial activity against NF54 chloroquine-sensitive and Dd2 chloroquine-resistant strains, alongside chloroquine and artesunate as reference compounds. Six of the test compounds revealed a 3-5 fold increase in antiplasmodial activity against chloroquine-resistant strain Dd2 compared to chloroquine. Among the six compounds with good antiplasmodial activity, a reduced cross-resistance relative to artesunate (>3 fold in comparison to chloroquine) was observed, mainly in derivatives that incorporated chloroquine-resistance reversing pharmacophores. A general trend for reduced chloroquine cross-resistance was also detected among 12 out of the 15 compounds tested.
One-pot synthesis of pharmacologically active diamines via rhodium- catalysed carbonylative hydroaminomethylation of heterocyclic allylic amines
Rische, Thorsten,Mueller, Kai-Sven,Eilbracht, Peter
, p. 9801 - 9816 (2007/10/03)
Pharmacologically active derivatives of phenothiazine, iminodibenzyl, carbazole and pyrazole are prepared with high yields and chemoselectivity by the reaction of the corresponding N-allylic or N-methallylic compounds, primary or secondary amines, carbon monoxide and hydrogen in the presence of [Rh(cod)Cl]2 as catalyst via a one pot hydroformylation - amine condensation - reduction sequence.
