64097-59-2

Basic information

• Product Name: 10,11-Dihydro-2-(1-pyrrolidinylmethyl)-5H-dibenz[b,f]azepine
• Synonyms: 10,11-Dihydro-2-(1-pyrrolidinylmethyl)-5H-dibenz[b,f]azepine
• CAS NO: 64097-59-2
• Molecular Formula: C19H22 N2
• Molecular Weight: 278.39
• Mol File: 64097-59-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 413.2°C at 760 mmHg
• Flash Point: 162.1°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 4.91E-07mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 10,11-Dihydro-2-(1-pyrrolidinylmethyl)-5H-dibenz[b,f]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 10,11-Dihydro-2-(1-pyrrolidinylmethyl)-5H-dibenz[b,f]azepine(64097-59-2)
• EPA Substance Registry System: 10,11-Dihydro-2-(1-pyrrolidinylmethyl)-5H-dibenz[b,f]azepine(64097-59-2)

Safety Data

• Hazardous Substances Data: 64097-59-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H22N2/c1-2-6-18-16(5-1)8-9-17-13-15(7-10-19(17)20-18)14-21-11-3-4-12-21/h1-2,5-7,10,13,20H,3-4,8-9,11-12,14H2

Upstream product

• 123-75-1 pyrrolidine 
• 50-00-0 formaldehyd 
• 494-19-9 9,10-dihydrodibenzazepine 

Relevant articles and documents

Aminomethylation de l'homoacridane, de l'iminodibenzyle et de l'iminostilbene

The aminomethylation of 6,11-dihydro-5H-dibenzoazepine (HA), 10,11-dihydro-5H-dibenzoazepine (IDB) and dibenzoazepine (ISB) was studied in order to evaluate modifications of antidepressive activities of these tricyclic structures.By reaction with formalin and a secondary amine in ethanol medium acidified by means of acetic acid, homoacridane (HA) leads to a monosubstitution product on carbone 2 (yield 50percent).Iminodibenzyl (IDB) and iminostilbene (ISB) also give monoaminomethylation products in analogous position (yields are respectively 74 and 59percent).In each case, the optimum amount of acetic acid has been determined.If acetic acid is used as the solvent, diaminomethylation is observed in positions 2 and 8 (yiels are 74percent for IDB and 59percent for ISB).Structures of the isolated products have been studied by IR and 1H nmr.The postulated mechanism of aromatic electrophilic substitution is discussed with respect to various factors: differences in basicities of heterocyclic amines; electronic structures and nitrogen activation of aromatic tricyclic systems; influence of amount of acetic acid on salification equilibria.