35674-27-2Relevant articles and documents
The solid phase synthesis of tri-substituted indoles
Collini, Michael D.,Ellingboe, John W.
, p. 7963 - 7966 (1997)
The palladium-catalyzed solid phase synthesis of tri-substituted indoles is described. The synthesis incorporates three independently variable groups and is ideally suited for the preparation of combinatorial libraries.
Thermal decomposition pathways of nitro-functionalized metal-organic frameworks
McDonald, Kyle A.,Ko, Nakeun,Noh, Kyungkyou,Bennion, Jonathan C.,Kim, Jaheon,Matzger, Adam J.
, p. 7808 - 7811 (2017)
The decomposition behavior of high energy metal-organic frameworks (MOFs) with extensive nitration is disclosed. In contrast to the detonation behavior observed in molecular energetic compounds, deflagration transforms cubic MOFs into anisotropic carbon s
Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions
Fu, Zhengjiang,Jiang, Ligao,Zuo, Qianming,Li, Zhaojie,Liu, Yanzhu,Wei, Zhenhong,Cai, Hu
, p. 5416 - 5421 (2018/08/12)
Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.
