412947-54-7

Basic information

• Product Name: METHYL 3-AMINO-4-IODOBENZOATE
• Synonyms: METHYL 3-AMINO-4-IODOBENZOATE;3-amino-4-iodobenzoic acid methyl ester
• CAS NO: 412947-54-7
• Molecular Formula: C₈H₈INO₂
• Molecular Weight: 277.06
• Mol File: 412947-54-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 134-136°C
• Boiling Point: 344.269 °C at 760 mmHg
• Flash Point: 162.008 °C
• Appearance: /
• Density: 1.827 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility: Slightly soluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: METHYL 3-AMINO-4-IODOBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-AMINO-4-IODOBENZOATE(412947-54-7)
• EPA Substance Registry System: METHYL 3-AMINO-4-IODOBENZOATE(412947-54-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• Hazardous Substances Data: 412947-54-7(Hazardous Substances Data)

Usage

Uses

Methyl 3-amino-4-iodobenzoate is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

InChI:InChI=1/C8H8INO2/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4H,10H2,1H3

Upstream product

• 89976-27-2 methyl ester of 4-iodo-3-nitrobenzoic acid 
• 1588-83-6 4-amino-3-nitrobenzoic acid 
• 35674-27-2 4-iodo-3-nitrobenzoic acid 
• 67-56-1 methanol 
• 51411-81-5 3-amino-4-iodo-benzoic acid 

Downstream Products

• 51411-81-5 3-amino-4-iodo-benzoic acid 
• 494799-11-0 methyl 4-iodo-3-[(2,2,2-trifluoroacetyl)amino]benzoate 
• 1006057-70-0 3-phenyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester 
• 1006057-78-8 2-phenyl-3-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester 
• 1006057-77-7 2-(4-methoxyphenyl)-3-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester 
• 1006057-69-7 3-(4-methoxyphenyl)-2-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester 
• 1006057-74-4 2-cyclopentyl-3-phenyl-1H-indole-6-carboxylic acid methyl ester 
• 1006057-64-2 3-cyclopentyl-2-phenyl-1H-indole-6-carboxylic acid methyl ester 
• 1093942-91-6 (S)-methyl 2-(4-benzyl-2-oxooxazolidin-3-yl)-1H-indole-6-carboxylate 

Relevant articles and documents

Preparation of 3-substituted-2-pyridin-2-ylindoles: regioselectivity of Larock's indole annulation with 2-alkynylpyridines

A regioselective Larock approach to 3-substituted-2-pyridin-2-ylindoles from 2-alkynylpyridines and 2-iodoanilines is described herein. The unexpectedly high regioselectivity can be rationalized by a combination of steric, coordinative and electronic effects.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Stereoselective synthesis of (E)-3-(methoxycarbonyl)methylene-1,3-dihydroindol-2-ones by palladium-catalyzed oxidative carbonylation of 2-ethynylanilines

A direct synthesis of (E)-3-(methoxycarbonyl)methylene-1,3-dihydroindol-2-ones 2 by palladium-catalyzed oxidative carbonylation of 2-ethynylanilines 1 is reported. Reactions were carried out in MeOH as the solvent at 50-70°C in the presence of catalytic a