494799-11-0

Basic information

• Product Name: Benzoic acid, 4-iodo-3-[(trifluoroacetyl)amino]-, methyl ester
• CAS NO: 494799-11-0
• Molecular Formula: C10H7F3INO3
• Molecular Weight: 373.07
• Mol File: 494799-11-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-iodo-3-[(trifluoroacetyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-iodo-3-[(trifluoroacetyl)amino]-, methyl ester(494799-11-0)
• EPA Substance Registry System: Benzoic acid, 4-iodo-3-[(trifluoroacetyl)amino]-, methyl ester(494799-11-0)

Safety Data

• Hazardous Substances Data: 494799-11-0(Hazardous Substances Data)

Upstream product

• 407-25-0 trifluoroacetic anhydride 
• 412947-54-7 methyl 3-amino-4-iodobenzoate 

Downstream Products

• 1612234-03-3 methyl 2',4'-dioxo-1-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-7'-carboxylate 
• 860359-98-4 methyl (2,3-diphenylindol-6-yl)carboxylate 
• 494799-12-1 4-phenylethynyl-3-(2,2,2-trifluoro-ethanoylamino)-benzoic acid methyl ester 

Relevant articles and documents

POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Regio- and chemoselective n-1 acylation of indoles: Pd-catalyzed domino cyclization to afford 1,2-fused tricyclic indole scaffolds

A concise method for the synthesis of 1,2-fused tricyclic indole scaffolds by domino cyclization involving a Pd-catalyzed Sonogashira coupling, indole cyclization, regio- and chemoselective N-1 acylation, and 1,4-Michael addition is reported. This method

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.