3569-00-4Relevant articles and documents
Bioinspired total synthesis of tetrahydrofuran lignans by tandem nucleophilic addition/redox isomerization/oxidative coupling and cycloetherification reactions as key steps
Jagtap, Pratap R.,Císa?ová, Ivana,Jahn, Ullrich
supporting information, p. 750 - 755 (2018/02/09)
A very short three-step approach to trans,trans,trans-2,5-diaryl-3,4-dimethyltetrahydrofuran lignans is reported. The carbon skeleton is assembled in a single step based on an unprecedented tandem reaction consisting of 1,2-addition of aryllithium reagents to α,β-unsaturated aldehydes, ruthenium-catalyzed redox isomerization of the resulting alkoxides to enolates and their dimerization triggered by single electron oxidation. The resulting 2,3-dialkyl-1,4-diketones form with moderate to good d/l-diastereoselectivity and are transformed to the target tetrahydrofuran lignans by reduction and diastereoselective cycloetherification.
Collective synthesis of several 2,7′-cyclolignans and their correlation by chemical transformations
Peng, Yu,Luo, Zhen-Biao,Zhang, Jian-Jian,Luo, Long,Wang, Ya-Wen
, p. 7574 - 7586 (2013/11/06)
Collective synthesis of anti-malarial 2,7′-cyclolignans has been stereoselectively achieved employing (±)-cyclogalgravin (2) as a linchpin through a series of functional group conversions, including redox reactions. Interestingly, 2 can be correlated with
Structure of Malabaricanol - A Lignan from the Aril of Myristica malabarica Lam.
Purushothaman, K. K.,Sarada, A.,Connolly, J. D.
, p. 46 - 48 (2007/10/02)
Malabaricanol, a lignan isolated from Myristica malabarica has been assigned the structure as β,β'-dimethyl-α,α'-bis(4-hydroxy-3-methoxyphenyl)tetrahydrofuran by spectroscopic and chemical methods.
