35793-61-4

Basic information

• Product Name: (S)-2-((R)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester
• CAS NO: 35793-61-4
• Molecular Weight: 536.623
• Mol File: 35793-61-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((R)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((R)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester(35793-61-4)
• EPA Substance Registry System: (S)-2-((R)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester(35793-61-4)

Safety Data

• Hazardous Substances Data: 35793-61-4(Hazardous Substances Data)

Upstream product

• 6234-01-1 L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride 
• 53838-27-0 H-Glu(tBu)-OMe 
• 51644-83-8 N-(benzyloxy)carbonyl-D-glutamic acid 5-tert-butyl ester 

Relevant articles and documents

Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors.

Based on bifunctional diketopiperazines as templates and m-aminomethyl-phenylalanine as arginine mimetic, we have synthesized a new class of structurally related dibasic tryptase inhibitors with systematically increasing spacer length. These compounds were used to scan the distance between the active sites of two neighboring subunits of the beta-tryptase tetramer. The K(i)-values obtained are a function of the distance between the terminal amino groups and indicate optimal binding of inhibitors with 29-31 bonds between the amino groups. These experimental data are in full agreement with predictions derived from a novel modeling program that allows the docking of bivalent ligands.