35817-47-1

Basic information

• Product Name: Quinoline, 8-chloro-4-Methyl-
• Synonyms: Quinoline, 8-chloro-4-Methyl-;8-Chloro-4-methyl-quinoline
• CAS NO: 35817-47-1
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.63022
• Mol File: 35817-47-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 294.2°Cat760mmHg
• Flash Point: 159.6°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.00289mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: Quinoline, 8-chloro-4-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 8-chloro-4-Methyl-(35817-47-1)
• EPA Substance Registry System: Quinoline, 8-chloro-4-Methyl-(35817-47-1)

Safety Data

• Hazardous Substances Data: 35817-47-1(Hazardous Substances Data)

Usage

General Description

Quinoline, 8-chloro-4-Methyl- is a chemical compound with the molecular formula C10H8ClN. It is a derivative of quinoline, which is a heterocyclic aromatic compound commonly found in coal tar and cigarette smoke. The 8-chloro-4-methyl substitution on the quinoline ring imparts specific properties to the compound, making it useful in various applications. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The compound also exhibits some biological activity and has been studied for its potential use in the treatment of cancer and other diseases. Additionally, it has been used as a building block in the production of dyes, pigments, and other organic compounds.

InChI:InChI=1/C10H8ClN/c1-7-5-6-12-10-8(7)3-2-4-9(10)11/h2-6H,1H3

Upstream product

• 62748-01-0 4-methyl-8-aminoquinoline 
• 815583-95-0 2,8-dichloro-4-methyl-quinoline 
• 6607-66-5 1,3,3-trimethoxybutane 
• 78-94-4 methyl vinyl ketone 
• 7647-01-0 hydrogenchloride 
• 7783-06-4 hydrogen sulfide 
• 7732-18-5 water 
• 95-51-2 o-chloroaniline 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 634-47-9 2-chloro-4-methylquinoline 
• 697801-13-1 2-chloro-4-methyl-[8]quinolylamine 
• 54904-38-0 8-chloro-4-methyl-quinolin-2-ol 
• 2801-29-8 4-methyl-8-nitroquinoline 
• 54965-58-1 2-chloro-4-methyl-8-nitroquinoline 

Downstream Products

• 109809-91-8 4-[trans-2-(8-chloro-[4]quinolyl)-vinyl]-N,N-dimethyl-aniline 
• 35839-88-4 8-chloroquinoline-4-carbaldehyde 

Relevant articles and documents

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Synthesis and antileishmanial evaluation of thiazole orange analogs

Cyanine compounds have previously shown excellent in vitro and promising in vivo antileishmanial efficacy, but the potential toxicity of these agents is a concern. A series of 22 analogs of thiazole orange ((Z)-1-methyl-4-((3-methylbenzo[d]thiazol-2(3H)-ylidene)methyl)quinolin-1-ium salt), a commercial cyanine dye with antileishmanial activity, were synthesized in an effort to increase the selectivity of such compounds while maintaining efficacy. Cyanines possessing substitutions on the quinolinium ring system displayed potency against Leishmania donovani axenic amastigotes that differed little from the parent compound (IC50 12–42 nM), while ring disjunction analogs were both less potent and less toxic. Changes in DNA melting temperature were modest when synthetic oligonucleotides were incubated with selected analogs (ΔTm ≤ 5 °C), with ring disjunction analogs showing the least effect on this parameter. Despite the high antileishmanial potency of the target compounds, their toxicity and relatively flat SAR suggests that further information regarding the target(s) of these molecules is needed to aid their development as antileishmanials.

AN IMPROVED PROCESS FOR THE SYNTHESIS OF QUINOLINE DERIVATIVES

The present invention provides an improved process for the synthesis of quinoline derivatives. More particularly the present invention provides an improved and economical process for the synthesis of quinoline derivatives by the reaction of aniline/substituted anilines using two different catalysts, ferric chloride and zinc chloride in a one-pot set up reaction.