3584-32-5

Basic information

• Product Name: 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID
• Synonyms: 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID
• CAS NO: 3584-32-5
• Molecular Formula: C₁₅H₁₃NO₆
• Molecular Weight: 303.26682
• Mol File: 3584-32-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID(3584-32-5)
• EPA Substance Registry System: 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID(3584-32-5)

Safety Data

• Hazardous Substances Data: 3584-32-5(Hazardous Substances Data)

Usage

General Description

4-BENZYLOXY-3-METHOXY-2-NITROBENZOIC ACID is a chemical compound with the molecular formula C15H13NO6. It is a nitrobenzoic acid derivative that contains a benzyl ether group and a methoxy group. 4-BENZYLOXY-3-METHOXY-2-NITROBENZOICACID is often used in organic synthesis as a reagent for creating new molecules and as a building block for pharmaceutical compounds. It has potential applications in the development of drugs and agrochemicals, as well as in material science and other industrial processes. The properties and reactivity of 4-BENZYLOXY-3-METHOXY-2-NITROBENZOIC ACID make it a valuable tool for the production of a wide range of chemical products.

Upstream product

• 2450-27-3 4-(benzyloxy)-3-methoxy-2-nitrobenzaldehyde 
• 2450-26-2 2-nitrovanillin 
• 100-44-7 benzyl chloride 

Downstream Products

• 23938-73-0 2-amino-3-methoxy-4-benzyloxybenzoic acid 
• 82354-35-6 des-N-methylnoracronycine 
• 135082-47-2 6-(benzyloxy)-1-hydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one 
• 135082-45-0 6-(benzyloxy)-1,2,3,4,5-pentamethoxyacridin-9-one 
• 135082-46-1 6-(benzyloxy)-10-methyl-1,2,3,4,5-pentamethoxyacridin-9-one 
• 135082-42-7 4-(benzyloxy)-3-methoxy-N-(2,3,4,5-tetramethoxyphenyl)anthranilic acid 
• 142003-89-2 6-(benzyloxy)-3,4-dimethoxy-10-methylacridine-1,2,9-trione 
• 142003-88-1 6-(benzyloxy)-2,3-dimethoxy-10-methylacridine-1,4,9-trione 
• 142003-86-9 6-(benzyloxy)-10-<2-(diethylamino)ethyl>-1,2,3,4,5-pentamethoxyacridin-9-one 
• 142003-90-5 3-(benzyloxy)-5-methyl-4,6,7-trimethoxyquino<3,2-a>phenazin-14(5H)-one 
• 1336890-54-0 4-(benzyloxy)-3-methoxy-2-nitroaniline 
• 861774-96-1 5.6-diamino-guaiacol 
• 1336890-53-9 tert-butyl 4-(benzyloxy)-3-methoxy-2-nitrophenylcarbamate 

Relevant articles and documents

Synthesis and biological evaluation of novel analogues of the pan class i phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474)

A structure-activity relationship (SAR) study of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2- yl]-1H-benzimidazole (ZSTK474) identified substitution at the 4 and 6 positions of the benzimidazole ring as having significant effects on the potency of substituted derivatives. The 6-amino-4-methoxy analogue displayed a greater than 1000-fold potency enhancement over the corresponding 6-aza-4-methoxy analogue against all three class Ia PI 3-kinase enzymes (p110α, p110β, and p110δ) and also displayed significant potency against two mutant forms of the p110α isoform (H1047R and E545K). This compound was also evaluated in vivo against a U87MG human glioblastoma tumor xenograft model in Rag1 -/- mice, and at a dose of 50 mg/kg given by ip injection at a qd ?- 10 dosing schedule it dramatically reduced cancer growth by 81% compared to untreated controls.