35975-86-1

Basic information

• Product Name: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS NO: 35975-86-1
• Molecular Formula: C₁₇H₁₃NO₃
• Molecular Weight: 279.29
• Mol File: 35975-86-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 459.1°C at 760 mmHg
• Flash Point: 231.5°C
• Density: 1.358g/cm³
• Vapor Pressure: 3.17E-09mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(35975-86-1)
• EPA Substance Registry System: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(35975-86-1)

Safety Data

• Hazardous Substances Data: 35975-86-1(Hazardous Substances Data)

Usage

Description

1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a chemical compound with potential pharmaceutical applications. It is a derivative of quinoline and contains a benzyl group, a carbonyl group, and a carboxylic acid group. Its unique structure and potential medicinal properties make it a subject of interest in the field of pharmaceutical chemistry.

Uses

Used in Pharmaceutical Industry:
1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is used as a therapeutic agent for its potential antimicrobial, anti-inflammatory, and antitumor properties. Research indicates that it may be effective in treating various diseases and conditions.
Used in Enzyme Inhibition:
1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is used as an inhibitor of certain enzymes, which can be beneficial in the development of drugs targeting specific biological processes.
Used in Biological Process Modulation:
1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is used to modulate biological processes, which can be useful in the treatment of various diseases and conditions by regulating specific pathways and mechanisms.

Upstream product

• 100-39-0 benzyl bromide 
• 52980-28-6 ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 53977-02-9 1-benzyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 
• 54535-22-7 diethyl (anilinomethylene)malonate 
• 289706-52-1 ethyl 2-(2',2',2'-trichloro)ethylidene-3-oxo-3-(2''-chlorophenyl)propionate 
• 289706-56-5 ethyl (2'-chlorophenyl)-3-oxo-2-(N-benzylamino)methylene propionate 
• 19112-35-7 ethyl (2-chlorobenzoyl)acetate 
• 62-53-3 aniline 
• 13721-01-2 4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 445-29-4 o-fluoro-benzoic acid 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1207748-75-1 ethyl 3-(benzylamino)-2-(2-fluorobenzoyl)-2-propenoate 
• 1353669-36-9 methyl 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 61707-79-7 1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester 

Downstream Products

• 91420-16-5 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 1622228-86-7 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 873054-44-5 ivacaftor 

Relevant articles and documents

Novel quinolin-4(1H)-one derivatives as multi-effective aldose reductase inhibitors for treatment of diabetic complications: Synthesis, biological evaluation, and molecular modeling studies

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Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor

A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop-Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.

A PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES

The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation of ivacaftor and pharmaceutically acceptable salt thereof using novel intermediates.