19112-35-7 Usage
Description
3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is an organic compound that serves as a versatile intermediate in the synthesis of various chemical products. It is characterized by its ester functional group and a chlorophenyl moiety, which contribute to its reactivity and potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant for the preparation of diaryl-substituted pyrazoles, which are potent CCR2 receptor antagonists. These antagonists have potential applications in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.
Used in Chemical Synthesis:
3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant in cerium ammonium nitrate-mediated oxidative coupling reactions. This process allows for the formation of new carbon-carbon bonds, which are essential in the synthesis of complex organic molecules.
Used in Hydrosilylation Reactions:
In the field of organometallic chemistry, 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant in hydrosilylation reactions. These reactions involve the addition of a silicon-hydrogen bond to an unsaturated carbon-carbon bond, leading to the formation of new organic compounds with potential applications in various industries.
Used in Agrochemical Industry:
3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant in the preparation of potential herbicidal agents. These agents are designed to control the growth of unwanted plants in agricultural fields, thereby increasing crop yield and reducing the need for manual labor.
Used in Asymmetric Catalysis:
3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant in ruthenium-catalyzed asymmetric hydrogenation reactions. This process allows for the selective reduction of prochiral compounds, leading to the formation of enantiomerically pure products. These products have potential applications in the synthesis of chiral pharmaceuticals and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 19112-35-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,1,1 and 2 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19112-35:
(7*1)+(6*9)+(5*1)+(4*1)+(3*2)+(2*3)+(1*5)=87
87 % 10 = 7
So 19112-35-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H11ClO3/c1-2-15-11(14)7-10(13)8-5-3-4-6-9(8)12/h3-6H,2,7H2,1H3
19112-35-7Relevant articles and documents
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Wierenga,W.,Skulnick,H.I.
, p. 310 - 311 (1979)
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Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes
Bai, Feifei,Fang, Jianguo,Song, Zi-Long,Zhang, Baoxin
, p. 2214 - 2231 (2020/03/06)
Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine-or H2O2-induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes' products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.
White mulberry root-bark active ingredient Morusin derivative and application and preparation method thereof
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Paragraph 0010, (2016/10/07)
The invention discloses a Morusin derivative and a preparation method. A Morusin total-synthesis route is adopted to achieve a structure modification scheme, in the process of Morusin total synthesis, structure modification is carried out by replacing sub
