67333-74-8

Basic information

• Product Name: 1-(2-chloro-benzoyl)-1H-imidazole
• Synonyms: 1-(2-chloro-benzoyl)-1H-imidazole
• CAS NO: 67333-74-8
• Molecular Weight: 206.631
• Mol File: 67333-74-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-(2-chloro-benzoyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloro-benzoyl)-1H-imidazole(67333-74-8)
• EPA Substance Registry System: 1-(2-chloro-benzoyl)-1H-imidazole(67333-74-8)

Safety Data

• Hazardous Substances Data: 67333-74-8(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 609-65-4 o-chlorobenzoyl chloride 
• 530-62-1 1,1'-carbonyldiimidazole 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 14367-94-3 1-(2-chlorophenyl)-2-nitroethan-1-one 
• 80282-51-5 2-Chloro-thiobenzoic acid S-tert-butyl ester 
• 19112-35-7 ethyl (2-chlorobenzoyl)acetate 
• 42766-13-2 5-(2-chlorophenyl)-3H-1,2-dithiole-3-thione 
• 6269-46-1 2-(2-chlorophenyl)-1,3-benzothiazole 
• 13182-90-6 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 2-chlorobenzoate 
• 65389-77-7 N-(2-aminoethyl)-2-chlorobenzamide 
• 609-66-5 2-chlorobenzamide 

Relevant articles and documents

Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine-or H2O2-induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes' products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Efficient CDI/CH3SO3H-catalyzed, microwave-assisted synthesis of 2-substituted benzothiazoles

CDI combined with CH3SO3H was found to be highly effective for the cyclization of 2-aminothiophenol derivatives with carboxylic acids under MW condition. Fourteen benzothiazole derivatives were synthesized in good yield and their structures were characterized by1H-NMR,13C-NMR, IR and mass spectrometry. This simple, rapid synthetic method is believed to provide a useful process for the synthesis of 2-substituted benzothiazole compounds.

A N, 6 diphenyl-pyrimidin-4-amine Bcr-Abl inhibitor and its preparation method and application

The invention discloses N,6 diphenylpyrimidine-4-amine Bcr-Abl inhibitors as well as a preparation method and application thereof. A structural formula of the inhibitors is shown in the specification, wherein in the structural formula, R is a mono-substituent or a di-substituent, and the substituent is alkyl, halogen or tertiary amino. The series of inhibitors have a certain inhibiting effect on ABL1 kinase in vitro, can inhibit tumor cell proliferation and can be used for preparing antitumor drugs, especially CML (chronic myelocytic leukemia) drugs. The preparation method of the N,6 diphenylpyrimidine-4-amine Bcr-Abl inhibitors, which is provided by the invention, has the advantages of easiness in obtainment of raw materials, mild reaction conditions, simplicity in operation of reaction processes and cheap used reagents.