359849-58-4

Basic information

• Product Name: (1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride
• Synonyms: (1S,2S)-2-AMINO-CYCLOPETANECARBOXYLIC ACID HYDROCHLORIDE SALT ;(1S,2S)-2-amino cyclopetanecarboxylic acid hydrochloride;(1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride;(1S,2S)-2-aminocyclopentanecarboxylicAcidHydrochloride
• CAS NO: 359849-58-4
• Molecular Formula: C6H11NO2.HCl
• Molecular Weight: 165.62
• Mol File: 359849-58-4.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: (1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride(359849-58-4)
• EPA Substance Registry System: (1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride(359849-58-4)

Safety Data

• Hazardous Substances Data: 359849-58-4(Hazardous Substances Data)

Usage

General Description

(1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride is a chemical compound that is a hydrochloride salt of a specific amino acid. It is a stereoisomer of 2-Amino-1-cyclopentanecarboxylic acid and is commonly used in organic synthesis and pharmaceutical research. Its unique structure and properties make it useful in the development of new drugs and therapeutic agents. (1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride has potential applications in the treatment of various medical conditions, and its stereochemistry is of particular interest in drug design and development. Additionally, its hydrochloride form makes it more stable and easier to handle in laboratory settings. Overall, (1S,2S)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride is a valuable chemical compound that has important implications in the field of pharmaceuticals and drug discovery.

InChI:InChI=1/C6H11NO2.ClH/c7-5-3-1-2-4(5)6(8)9;/h4-5H,1-3,7H2,(H,8,9);1H/t4-,5-;/m0./s1

Upstream product

• 569679-90-9 (2S,3S,4E,αS)-tert-butyl 2-allyl-3-(N-α-methylbenzylamino)-N-benzyloxycarbonyl-hex-4-enoate 
• 569679-87-4 (2S,3S,4E,αS)-tert-butyl 2-allyl-3-(N-α-methylbenzylamino)-hex-4-enoate 
• 532990-00-4 (1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclopent-3-enecarboxylic acid benzyl ester 
• 569679-98-7 (1S,2S,αS)-tert-butyl 2-N-α-methylbenzylamino-N-benzyloxycarbonyl-cyclopent-3-ene-1-carboxylate 
• 359586-68-8 (1S,2S)-2-[(1'S)-phenylethyl]aminocyclopentanecarboxylic acid 
• 1609100-30-2 ethyl cis-2-aminocyclopentane-1-carboxylate 
• 197916-36-2 ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate 
• 1039114-07-2 (1R,2S)-2-Isocyanato-cyclopentanecarboxylic acid methyl ester 
• 592503-41-8 cis-2-acetylaminocyclopentanecarboxylic acid ethyl ester 
• 7149-18-0 ethyl 2-amino-1-cyclopentene-1-carboxylate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 142-29-0 cyclopentene 
• 39155-95-8 (1S,5R)-6-azabicyclo<3.2.0>heptan-7-one 
• 22031-52-3 cis-2-aza-3-oxobicyclo<3.2.0>heptane 

Downstream Products

• 282524-97-4 rel-(1R,2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}cyclopentanecarboxylic acid 

Relevant articles and documents

The N-Hydroxymethyl Group as a Traceless Activating Group for the CAL-B-Catalysed Ring Cleavage of β-Lactams: A Type of Two-Step Cascade Reaction

An efficient enzymatic two-step cascade procedure has been devised for rapid access to diverse amino acids from N-hydroxymethyl-β-lactams; representative amino acids include the antifungal agent cispentacin, intermediates for the taxol side-chain, and assorted cathepsin inhibitors. When CAL-B-catalysed hydrolyses of racemic N-hydroxymethyl-β-lactams were performed with H2O (0.5 equiv.) in iPr2O at 60 °C, relatively quick (vs. non-activated counterparts) and enantioselective (E > 200) ring cleavage reactions took place. As the ring-opened amino acids formed, the hydroxymethyl group, as a traceless activating group, underwent spontaneous in situ degradation. Consequently, the desired β-amino acid and unreacted N-hydroxymethyl-β-lactam enantiomers (ee > 95 %) were formed. The formation of polymers, induced by liberation of formaldehyde, was successfully restricted by the addition of benzylamine as a capture agent, to the enzymatic reactions. An efficient enzymatic two-step cascade procedure was devised for CAL-B-catalysed hydrolysis of racemic N-hydroxymethyl-β-lactams. Conditions in which the hydroxymethyl group serves as a traceless activating group (E > 200), giving desired β-amino acid along with unreacted starting lactam enantiomers (ee > 95 %) were identified; polymerization was controlled by addition benzylamine addition.

Hairpin folding behavior of mixed α/β-peptides in aqueous solution

The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the α-helix, mimicry of protein β-sheets is less understood. We report

NEW COMPOUNDS

The present invention encompassescompounds of general formula (1) wherein R1 to R4 , X and n are defined as in claim 1, which are suitable for the treatment of ailments characterised byexcessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.