359867-36-0Relevant articles and documents
Pyrano, piperidino, and thiopyrano compounds and methods of use
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, (2008/06/13)
The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiaryamino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein
Massa, Mark A.,Spangler, Dale P.,Durley, Richard C.,Hickory, Brian S.,Connolly, Daniel T.,Witherbee, Bryan J.,Smith, Mark E.,Sikorski, James A.
, p. 1625 - 1628 (2007/10/03)
A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols has been prepared as potent inhibitors of cholesteryl ester transfer protein (CETP). Modifying the aromatic 3-tetrafluoroethoxy group in the lead molecule 1a with various heteroaryl moietie