77771-02-9Relevant articles and documents
A 3 - bromo -4 - fluoro benzaldehyde synthetic method
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Paragraph 0024-0050, (2019/07/05)
The present invention relates to the technical field of agricultural chemicals or pharmaceutical intermediate synthesis, in particular to a 3 - bromo - 4 - fluoro benzaldehyde synthetic method, comprises the following steps: (1) the 4 - fluorophenyl formaldehyde dissolved in methylene chloride, to obtain solution A; (2) the sodium bromide is dissolved in pure water, stirring while adding 35% hydrochloric acid, to obtain solution B; (3) the solution and the solution after mixing A B, opening ultrasonic, dropping sodium hypochlorite aqueous solution; (4) [...], ultrasonic, thermal insulation under stirring, then standing; (5) split-phase, dichloromethane phase washed to neutral, drying desolvation; (6) it is crude, 31 °C body melt crystallization, to get the pure product. The synthetic method does not require the use of a catalyst, in the process does not involve the precursor chemicals or toxic chlorine bromine; raw materials are easy, low-risk; high yield; process green, easy operation, and environmental protection.
PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols
Fujimoto, Teppei,Ritter, Tobias
supporting information, p. 544 - 547 (2015/03/05)
A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.
Solvent-free oxidation of alcohols with potassium persulphate in the presence of bronsted acidic ionic liquids
Chaskar,Bhandari,Patil,Sharma,Mayeker
experimental part, p. 366 - 370 (2009/04/07)
An efficient conversion of alcohols to aldehydes was achieved using potassium persulphate and 3-methylimidazolinium methane sulfonate. Copyright Taylor & Francis Group, LLC.