361345-36-0

Basic information

• Product Name: tert-butyl 4-(2-methyl-4-nitrophenyl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(2-methyl-4-nitrophenyl)piperazine-1-carboxylate
• CAS NO: 361345-36-0
• Molecular Weight: 321.376
• Mol File: 361345-36-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 471.0±45.0 °C(Predicted)
• Density: 1.198±0.06 g/cm3(Predicted)
• CAS DataBase Reference: tert-butyl 4-(2-methyl-4-nitrophenyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2-methyl-4-nitrophenyl)piperazine-1-carboxylate(361345-36-0)
• EPA Substance Registry System: tert-butyl 4-(2-methyl-4-nitrophenyl)piperazine-1-carboxylate(361345-36-0)

Safety Data

• Hazardous Substances Data: 361345-36-0(Hazardous Substances Data)

Upstream product

• 455-88-9 5-nitro-2-fluorotoluene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 7149-70-4 2-bromo-5-nitrotoluene 
• 446-33-3 5-Fluoro-2-nitrotoluene 

Downstream Products

• 1390656-67-3 tert-butyl 4-(4-(7-chloro-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-2-methylphenyl)piperazine-1-carboxylate 
• 1390656-68-4 tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-2-methylphenyl)piperazine-1-carboxylate 
• 808196-28-3 tert-butyl 4-(4-iodo-2-methylphenyl)piperazine-1-carboxylate 
• 1048664-05-6 1-(2-methyl-4-nitrophenyl)piperazine dihydrochloride 
• 361345-37-1 1-(t-butoxycarbonyl)-4-(4-amino-3-methylbenzene)sulphonylpiperazinide 

Relevant articles and documents

Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors

Fms-like tyrosine kinase 3 (FLT3) has been considered as a potential drug target for the treatment of acute myeloid leukemia (AML), because of its high and aberrant expression in AML patients, especially the patients with FLT3-ITD mutation. Initiating from a hit compound (IC50: 500 nM against FLT3-ITD), a series of compounds were designed and synthesized based on benzo[d]oxazole-2-amine scaffold to discover new potent FLT3-ITD inhibitors. During the medicinal chemistry works, flexible molecular docking was used to provide design rationale and study the binding modes of the target compounds. Through the mixed SAR exploration based on the enzymatic and cellular activities, compound T24 was identified with potent FLT3-ITD inhibitory (IC50: 0.41 nM) and anti-proliferative (IC50: 0.037 μM against MV4-11 cells) activities. And the binding mode of T24 with “DFG-in” FLT3 was simulated by a 20-ns molecular dynamics run, providing some insights into further medicinal chemistry efforts toward novel FLT3 inhibitors in AML therapy.

PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS

The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES

Compounds of formula (I) or pharmaceutical acceptable salts are provided, wherein X1~X5, R1~R3, A, B, Z and n are defined in the description. And compositions containing said compounds, and the uses for inhibitors of kinases such as ALK, and the uses for treating cancer thereof are provided.