361345-37-1

Basic information

• Product Name: 4-(4-Boc-piperazin-1-yl)-3-methylaniline
• Synonyms: 4-(4-Boc-piperazin-1-yl)-3-methylaniline;tert-butyl 4-(4-amino-2-methylphenyl)piperazine-1-carboxylate
• CAS NO: 361345-37-1
• Molecular Formula: C16H25N3O2
• Molecular Weight: 291.39
• Mol File: 361345-37-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 450.028°C at 760 mmHg
• Flash Point: 225.969°C
• Appearance: /
• Density: 1.127g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• PKA: 7.81±0.10(Predicted)
• CAS DataBase Reference: 4-(4-Boc-piperazin-1-yl)-3-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Boc-piperazin-1-yl)-3-methylaniline(361345-37-1)
• EPA Substance Registry System: 4-(4-Boc-piperazin-1-yl)-3-methylaniline(361345-37-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 361345-37-1(Hazardous Substances Data)

Usage

General Description

4-(4-Boc-piperazin-1-yl)-3-methylaniline is a chemical compound consisting of a piperazine ring with a Boc protecting group and a 3-methylaniline moiety. The piperazine ring is a heterocyclic organic compound that is often used as a building block in the synthesis of various pharmaceuticals and chemical agents. The Boc protecting group is commonly used in organic synthesis to protect amine functional groups from undesired side reactions. The 3-methylaniline moiety is a substituted aniline derivative that is utilized in the production of dyes, pharmaceuticals, and other organic compounds. Overall, 4-(4-Boc-piperazin-1-yl)-3-methylaniline is a versatile chemical with potential applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C16H25N3O2/c1-12-11-13(17)5-6-14(12)18-7-9-19(10-8-18)15(20)21-16(2,3)4/h5-6,11H,7-10,17H2,1-4H3

Upstream product

• 361345-36-0 tert-butyl 4-(2-methyl-4-nitrophenyl)piperazine-1-carboxylate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 7149-70-4 2-bromo-5-nitrotoluene 
• 455-88-9 5-nitro-2-fluorotoluene 

Downstream Products

• 808196-28-3 tert-butyl 4-(4-iodo-2-methylphenyl)piperazine-1-carboxylate 

Relevant articles and documents

PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF

The present invention discloses a pyrimidine compound, a preparation method thereof and a medical use thereof. Specifically, the present invention discloses a pyrimidine compound represented by formula (I), pharmaceutically acceptable salts thereof, a preparation method thereof, and a use thereof as a cyclin-dependent kinase 9 (CDK9) inhibitor, particularly for the treatment of cancer. The definition of each group in formula (I) is the same as that in the specification.

Thiazolidine derivatives or salts thereof as an active ingredient an inhibitor Pim

PROBLEM TO BE SOLVED: To provide compounds which have excellent Pim inhibitory action and are useful as pharmaceuticals.SOLUTION: A compound is a thiazolidine derivative represented by the general formula (1) in the figure, or a salt thereof. (In the formula, X represents O or S; Rrepresents a hydrogen atom or a Calkyl group; Z, Z, Z, Z, Zand Zeach independently represent CH or N; Y represents an optionally substituted, divalent Caromatic hydrocarbon group or the like; Am represents a disubstituted amino group, or an optionally substituted, nitrogen-containing saturated heterocyclic group; and Rand Reach independently represent a hydrogen atom, a halogen atom, an alkyl group or the like.)

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R1, X, Y, Z, A, B, G1, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.