36155-35-8

Basic information

• Product Name: 2-[(4-CHLOROPHENYL)THIO]ETHANAMINE
• Synonyms: 2-[(4-chlorophenyl)thio]ethanamine(SALTDATA: FREE);EthanaMine, 2-[(4-chlorophenyl)thio]-
• CAS NO: 36155-35-8
• Molecular Formula: C₈H₁₀ClNS
• Molecular Weight: 187.69
• Mol File: 36155-35-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 288.1°C at 760 mmHg
• Flash Point: 128.1°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 0.00238mmHg at 25°C
• Refractive Index: 1.607
• PKA: 8.65±0.10(Predicted)
• CAS DataBase Reference: 2-[(4-CHLOROPHENYL)THIO]ETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-CHLOROPHENYL)THIO]ETHANAMINE(36155-35-8)
• EPA Substance Registry System: 2-[(4-CHLOROPHENYL)THIO]ETHANAMINE(36155-35-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 36155-35-8(Hazardous Substances Data)

Usage

General Description

2-[(4-Chlorophenyl)thio]ethanamine is a chemical compound with the formula C8H10ClNS. It is also known as 4-Methylthioamphetamine (4-MTA) and is a synthetic amphetamine derivative that has stimulant and hallucinogenic effects. It is classified as a Schedule I controlled substance in the United States due to its potential for abuse and addiction. 4-MTA is known for its neurotoxicity and has been linked to several deaths and hospitalizations. It acts on the central nervous system by increasing the levels of dopamine, norepinephrine, and serotonin in the brain, leading to altered mood, perception, and behavior. Due to its harmful effects, 4-MTA is illegal in many countries and its recreational use is highly discouraged.

InChI:InChI=1/C8H10ClNS/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4H,5-6,10H2

Upstream product

• 151-56-4 ethyleneimine 
• 106-54-7 p-Chlorothiophenol 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 497-25-6 dimethylenecyclourethane 

Downstream Products

• 112626-21-8 N-[2-(4-chloro-phenylsulfanyl)-ethyl]-N'-diethoxyphosphoryl-thiourea 
• 100380-13-0 3-methyl-crotonic acid-[2-(4-chloro-phenylsulfanyl)-ethylamide] 
• 53492-49-2 3-[2-(4-chloro-phenylsulfanyl)-ethyl]-sydnone 
• 53492-55-0 3-[2-(4-chloro-phenylsulfanyl)-ethyl]-4-methyl-sydnone 
• 133760-86-8 2-[2-(4-Chloro-phenylsulfanyl)-ethylamino]-1-phenyl-ethanol 
• 361145-75-7 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(4-chlorophenyl)thio]ethyl}-1-isoindolinone 
• 133760-76-6 3-[2-(4-Chloro-phenylsulfanyl)-ethyl]-5-phenyl-oxazolidin-2-one 
• 133760-80-2 1-[2-(4-Chloro-phenylsulfanyl)-ethyl]-4-phenyl-imidazolidin-2-one 
• 913818-13-0 [FeCl₂((CH₃)2C₆H₃NC₁₂H₆NCH₂CH₂SC₆H₄Cl)]2 
• 945653-12-3 [CoCl₂((CH(CH₃)2)2C₆H₃NC₁₂H₆NCH₂CH₂SC₆H₄Cl)]2 

Relevant articles and documents

Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases

Chlamydia trachomatis is the most common sexually transmitted bacterial disease globally and the leading cause of infertility and preventable infectious blindness (trachoma) in the world. Unfortunately, there is no FDA-approved treatment specific for chlamydial infections. We recently reported two sulfonylpyridines that halt the growth of the pathogen. Herein, we present a SAR of the sulfonylpyridine molecule by introducing substituents on the aromatic regions. Biological evaluation studies showed that several analogues can impair the growth of C. trachomatis without affecting host cell viability. The compounds did not kill other bacteria, indicating selectivity for Chlamydia. The compounds presented mild toxicity toward mammalian cell lines. The compounds were found to be nonmutagenic in a Drosophila melanogaster assay and exhibited a promising stability in both plasma and gastric fluid. The presented results indicate this scaffold is a promising starting point for the development of selective antichlamydial drugs.

N-acylsulfonamide apoptosis promoters

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