362607-78-1

Basic information

• Product Name: 1-(3,5-di-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil
• CAS NO: 362607-78-1
• Molecular Weight: 504.419
• Mol File: 362607-78-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3,5-di-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-di-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil(362607-78-1)
• EPA Substance Registry System: 1-(3,5-di-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil(362607-78-1)

Safety Data

• Hazardous Substances Data: 362607-78-1(Hazardous Substances Data)

Upstream product

• 362607-77-0 1-(3,5-di-O-benzoyl-β-L-xylo-furanosyl)-5-(trifluoromethyl)uracil 
• 667875-91-4 1-(2-O-acetyl-3,5-di-O-benzoyl-β-L-xylo-furanosyl)-5-(trifluoromethyl)uracil 
• 201287-82-3 1,2-di-O-acetyl-3,5-di-O-benzoyl-β-L-xylofuranosyle 
• 54-20-6 5-trifluoromethyluracil 

Downstream Products

• 362607-80-5 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil 

Relevant articles and documents

Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives

Recently, β-L-nucleoside analogues have emerged as a new class of sugar modified nucleosides with potential antiviral and/or antitumoral activity. As a part of our ongoing research on this topic, we decided to synthesize 5-CF3-β-L-dUrd (7), the hitherto unknown L-enantiomer of Trifluridine, an antiherpetic drug approved by FDA but only used in topical applications due to concomitant cytotoxicity. 5-CF3-β-dUrd (7) as well as some other related L-nucleoside derivatives were stereospecifically prepared and tested in vitro against viral (HSV-1 and HSV-2) and human thymidine kinases (TK).