362607-80-5

Basic information

• Product Name: 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil
• Synonyms: 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil
• CAS NO: 362607-80-5
• Molecular Weight: 400.311
• Mol File: 362607-80-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil(362607-80-5)
• EPA Substance Registry System: 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil(362607-80-5)

Safety Data

• Hazardous Substances Data: 362607-80-5(Hazardous Substances Data)

Upstream product

• 667875-91-4 1-(2-O-acetyl-3,5-di-O-benzoyl-β-L-xylo-furanosyl)-5-(trifluoromethyl)uracil 
• 362607-77-0 1-(3,5-di-O-benzoyl-β-L-xylo-furanosyl)-5-(trifluoromethyl)uracil 
• 362607-78-1 1-(3,5-di-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil 
• 201287-82-3 1,2-di-O-acetyl-3,5-di-O-benzoyl-β-L-xylofuranosyle 
• 54-20-6 5-trifluoromethyluracil 
• 98-88-4 benzoyl chloride 
• 362607-79-2 1-(2-deoxy-β-L-threo-pentofuranosyl)-5-(trifluoromethyl)uracil 

Relevant articles and documents

5-(trifluoromethyl)-β-L-2′-deoxyuridine, the L-enantiomer of trifluorothymidine: Stereospecific synthesis and antiherpetic evaluations

As part of our ongoing work on β-L-nucleoside analogues as potential antiviral drugs, we have synthesized 5-(tri-fluoromethyl)-β-L-2′-deoxyuridine (L-TFT), the hitherto unknown L-enantiomer of trifluorothymidine (CF3dUrd, TFT). We have also studied the effect of L-TFT on human and herpes simplex virus (HSV) type 1 and 2 thymidine kinases, and human thymidine phosphorylase, as well as its anti-HSV-1 and anti-HSV-2 activities in cell cultures. L-TFT has been found: (i) to inhibit HSV-1 TK with activity comparable to TFT, with no effect on human TK, (ii) to be phosphorylated by the viral enzyme with similar efficiency to TFT, (iii) to be resistant, in contrast to TFT, to hydrolysis by human thymidine phosphorylase. Unfortunately, when evaluated in cell cultures, L-TFT did not show any anti-HSV-1 and anti-HSV-2 activities. Copyright