363-40-6

Basic information

• Product Name: 2',4',6'-TRIFLUOROACETANILIDE
• Synonyms: 2',4',6'-TRIFLUOROACETANILIDE;2,4,6-TRIFLUOROACETANILIDE;N-(2,4,6-Trifluorophenyl)acetamide
• CAS NO: 363-40-6
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.13
• Mol File: 363-40-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 152-154
• Boiling Point: 247.8°C at 760 mmHg
• Flash Point: 103.6°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 0.0252mmHg at 25°C
• Refractive Index: 1.511
• PKA: 11.93±0.70(Predicted)
• CAS DataBase Reference: 2',4',6'-TRIFLUOROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4',6'-TRIFLUOROACETANILIDE(363-40-6)
• EPA Substance Registry System: 2',4',6'-TRIFLUOROACETANILIDE(363-40-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 363-40-6(Hazardous Substances Data)

Usage

General Description

2',4',6'-Trifluoroacetanilide, also known as TFAA, is a chemical compound with the molecular formula C8H7F3NO. It is a derivative of acetanilide, a common building block in organic synthesis. 2',4',6'-Trifluoroacetanilide is often used as a reagent in pharmaceutical and agrochemical industries for the synthesis of various compounds. It is a white solid with a melting point of 101-103°C and has a slightly toxic nature. This chemical has also been used as an intermediate in the production of organic compounds and has applications in research and development processes. Overall, 2',4',6'-Trifluoroacetanilide is a versatile chemical with various industrial and research applications.

InChI:InChI=1/C8H6F3NO/c1-4(13)12-8-6(10)2-5(9)3-7(8)11/h2-3H,1H3,(H,12,13)

Upstream product

• 363-81-5 2,4,6-trifluoroaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 153937-30-5 2-Amino-3,5-difluoro-benzenethiol 
• 123797-03-5 C₆H₃F₃N₂ 
• 123825-40-1 C₆HF₃N₂ 
• 123797-02-4 2,4,6-trifluoro-1,3-diazobenzene 
• 123797-07-9 2,4,6-trifluoro-1,3-phenylenediamine 

Relevant articles and documents

Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications

Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective 3-[(benzothiazol-2-yl)methyl]indole-N-alkanoic acid aldose reductase inhibitors. The lead candidate, 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat, 9) inhibits aldose reductase with an IC50 of 5 nM, while being 5400 times less active against aldehyde reductase, a related enzyme involved in the detoxification of reactive aldehydes. It lowers nerve and lens sorbitol levels with ED50's of 1.9 and 4.5 mg/kg/d po, respectively, in the 5-day STZ-induced diabetic rat model. In a 3-month diabetic intervention model (1 month of diabetes followed by 2 months of drug treatment at 5 mg/kg/d po), it normalizes polyols and reduces the motor nerve conduction velocity deficit by 59% relative to diabetic controls. It has a favorable pharmacokinetic profile (F, 82%; t1/2, 5.6 h; Vd, 0.694 L/kg) with good drug penetration in target tissues (Cmax in sciatic nerve and eye are 2.36 and 1.45 μg equiv/g, respectively, when dosed with [14C] lidorestat at 10 mg/kg po).