363-73-5

Basic information

• Product Name: 2,3,4,6-TETRAFLUOROANILINE
• Synonyms: 2,3,4,6-TETRAFLUOROANILINE;4-fluro-2-methylaniline;2,3,4,6-Tetrafluoroaniline 97%;2,3,4,6-Tetrafluoroaniline97%;(2,3,4,6-tetrafluorophenyl)amine;2,3,4,6-TETRAFLUOROA
• CAS NO: 363-73-5
• Molecular Formula: C6H3F4N
• Molecular Weight: 165.09
• EINECS: 206-659-2
• Product Categories: Indolines ,Indoles
• Mol File: 363-73-5.mol
• Article Data: 52

Chemical Properties

• Melting Point: 23-26
• Boiling Point: 65 °C20 mm Hg(lit.)
• Flash Point: 136 °F
• Appearance: /
• Density: 1.5 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.02mmHg at 25°C
• Refractive Index: n20/D 1.462(lit.)
• PKA: 0.85±0.10(Predicted)
• CAS DataBase Reference: 2,3,4,6-TETRAFLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,6-TETRAFLUOROANILINE(363-73-5)
• EPA Substance Registry System: 2,3,4,6-TETRAFLUOROANILINE(363-73-5)

Safety Data

• Hazard Codes: Xn,T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 363-73-5(Hazardous Substances Data)

Usage

General Description

2,3,4,6-Tetrafluoroaniline is a chemical compound with the molecular formula C6H4F4N. It is a flammable, colorless to light brown liquid with a faint aromatic odor. 2,3,4,6-TETRAFLUOROANILINE is primarily used as an intermediate in the production of agricultural chemicals, dyes, and other specialty chemicals. It is also utilized as a building block in the synthesis of pharmaceuticals and other organic compounds. 2,3,4,6-Tetrafluoroaniline is known to be toxic if swallowed, inhaled, or absorbed through the skin, and can cause irritation to the skin, eyes, and respiratory system. It should be handled with care and in accordance with proper safety precautions.

InChI:InChI=1/C6H3F4N/c7-2-1-3(8)6(11)5(10)4(2)9/h1H,11H2

Upstream product

• 314-41-0 1,2,3,5-tetrafluoro-4-nitrobenzene 
• 623-39-2 glycerol 1-monomethyl ether 
• 67-56-1 methanol 
• 106-89-8 epichlorohydrin 
• 1072-61-3 4-chloromethyl-[1,3]dioxolane 
• 107-05-1 3-chloroprop-1-ene 
• 1634-04-4 tert-butyl methyl ether 

Downstream Products

• 130020-18-7 3-(2,3,4,6-tetrafluorophenyl)imino-2H-indol-2-one 
• 332903-66-9 2-chloro-N-(2,3,4,6-tetrafluorophenyl)-N-p-tolyl-acetamide 
• 130020-24-5 C₁₆H₈F₄N₂O₂S 
• 76072-21-4 N-2,3,4,6-tetrafluorophenyl-N'-2,6-difluorobenzoylurea 
• 80025-73-6 3-H-C₆F₄NHNH₂ 

Relevant articles and documents

On the mechanism of alcoholysis of allylic and benzylic alcohols and of epoxides in the presence of ceric ammonium nitrate

The methanolysis of allylic alcohols, benzylic tertiary alcohols and epoxides in the presence of a catalytic amount of ceric ammonium nitrate (CAN) is shown to be catalysed by protons generated from the oxidation of methanol. This reaction is also catalysed by Lewis acids.

Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: Synthesis, structure, and biological properties

It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, alkylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride ether-ate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypropyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolec-ular structure of the obtained phosphonium salts was established, and their high antitumor activity was revealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phosphonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailabil-ity and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells.

Selective synthesis of epichlorohydrin: Via liquid-phase allyl chloride epoxidation over a modified Ti-MWW zeolite in a continuous slurry bed reactor

The epoxidation of allyl chloride (ALC) to epichlorohydrin (ECH) with H2O2 using a piperidine (PI)-modified Ti-MWW catalyst (Ti-MWW-PI) in a continuous slurry reactor was investigated to develop an efficient reaction system for the corresponding industrial process. The reaction parameters, including solvent, reaction temperature, t-butanol/ALC mass ratio, ALC/H2O2 molar ratio, weight hourly space velocity of H2O2, and the addition amount of ammonia, were studied in detail to pursue high H2O2 conversion and ECH selectivity. A long catalytic lifetime of 244 h was achieved at high H2O2 conversion (>97.0%) and ECH selectivity (>99.8%) under optimized reaction conditions. The crystallinity was well maintained for the deactivated Ti-MWW-PI catalyst, which was regenerated by a combination of calcination and piperidine treatment. This journal is