363191-03-1

Basic information

• Product Name: [(1R)-2-[4-Cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]carbamic Acid 1,1-dimethylethyl Ester
• Synonyms: [(1R)-2-[4-Cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]carbamic Acid 1,1-dimethylethyl Ester
• CAS NO: 363191-03-1
• Molecular Weight: 531.711
• Mol File: 363191-03-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: [(1R)-2-[4-Cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]carbamic Acid 1,1-dimethylethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R)-2-[4-Cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]carbamic Acid 1,1-dimethylethyl Ester(363191-03-1)
• EPA Substance Registry System: [(1R)-2-[4-Cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]carbamic Acid 1,1-dimethylethyl Ester(363191-03-1)

Safety Data

• Hazardous Substances Data: 363191-03-1(Hazardous Substances Data)

Upstream product

• 674791-75-4 C₇H₈O₃S*C₁₂H₂₁NO₂ 
• 674791-76-5 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride 
• 852323-76-3 1-tert-butoxycarbonyl 4-tert-butylcarbamoyl-4-cyclohexylpiperidine 
• 852323-77-4 1-BOC-4-cyclohexyl-4-piperidinecarbonyl chloride 
• 273378-16-8 (1-tert-butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid 
• 363191-02-0 N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide 

Downstream Products

• 747409-31-0 C₄₀H₅₈FN₅O₃ 
• 1309060-03-4 C₃₂H₅₀FN₅O₃ 
• 1309060-02-3 C₃₃H₅₂FN₅O₃ 
• 674792-27-9 fluoro-(D)-Phe,t-butyl amide dipeptide 
• 363191-06-4 4-(2-tert-butoxycarbonylamino-propionyl)-2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 363189-17-7 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 363189-18-8 (2S)-2-[[[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]amino]carbonyl]-1,4-piperazinedicarboxylic Acid 1-(1,1-dimethylethyl) 4-(phenylmethyl) Ester 
• 363190-30-1 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 363189-67-7 (S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester 
• 491845-84-2 (1S,4R,6S)-6-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester 
• 491845-85-3 (1R,4S,6R)-6-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino] carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl] -4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. Further in vivo development of lead agonist, MB243, is disclosed.

PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders r