364793-55-5

Basic information

• Product Name: 3-Quinolinecarbonitrile, 6-bromo-4-[(2,4-dichloro-5-methoxyphenyl)amino]-
• CAS NO: 364793-55-5
• Molecular Formula: C17H10BrCl2N3O
• Molecular Weight: 423.096
• Mol File: 364793-55-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarbonitrile, 6-bromo-4-[(2,4-dichloro-5-methoxyphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 6-bromo-4-[(2,4-dichloro-5-methoxyphenyl)amino]-(364793-55-5)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 6-bromo-4-[(2,4-dichloro-5-methoxyphenyl)amino]-(364793-55-5)

Safety Data

• Hazardous Substances Data: 364793-55-5(Hazardous Substances Data)

Upstream product

• 364793-52-2 6-bromo-4-oxo-1,4-dihydroquinoline-3-carbonitrile 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 364793-54-4 6-bromo-4-chloro-3-quinolinecarbonitrile 
• 98446-49-2 2,4-dichloro-5-methoxyaniline 

Downstream Products

• 1190759-67-1 C₂₈H₂₆Cl₂N₆O 
• 946491-02-7 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-[(1E)-4-morpholin-4-ylbut-1-enyl]quinoline-3-carbonitrile 
• 364788-62-5 4-(2,4-dichloro-5-methoxy-phenylamino)-6-(5-formyl-thiophen-3-yl)-quinoline-3-carbonitrile 

Relevant articles and documents

Further studies on ethenyl and ethynyl-4-phenylamino-3- quinolinecarbonitriles: Identification of a subnanomolar Src kinase inhibitor

Several new ethynyl- and ethenyl-4-phenylamino-3-quinolinecarbonitriles were synthesized and tested for Src inhibition. Derivatives bearing an ethenyl or ethynyl substituent at C-6 showed decreased Src inhibitory activity. Incorporation of an ethenylpyridine N-oxide group at C-7 provided 20b, a 0.6 nM inhibitor of Src enzymatic activity with excellent cellular potency.

3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors

This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.