366-84-7

Basic information

• Product Name: 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER
• Synonyms: RARECHEM AL BW 1094;4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER
• CAS NO: 366-84-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: pharmacetical
• Mol File: 366-84-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER(366-84-7)
• EPA Substance Registry System: 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER(366-84-7)

Safety Data

• Hazardous Substances Data: 366-84-7(Hazardous Substances Data)

Usage

General Description

4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER, also known as ethyl 4-aminobenzoate or benzocaine, is an ester derivative of para-aminobenzoic acid with a local anesthetic and antiarrhythmic properties. It is commonly used as a topical pain reliever, particularly in creams, ointments, and sprays for the temporary relief of minor skin irritations, itching, and pain caused by insect bites, poison ivy, and sunburn. Benzocaine works by blocking nerve signals in the body and is also used in dentistry as a numbing agent for toothaches and other oral discomfort. Additionally, it is sometimes used in combination with other analgesics and antiseptics in first aid treatments.

Upstream product

• 56-91-7 p-aminomethylbenzoic acid 
• 64-17-5 ethanol 
• 7153-22-2 ethyl 4-cyanobenzoate 
• 100-97-0 hexamethylenetetramine 
• 1201-90-7 ethyl 4-chloromethylbenzoate 
• 26496-94-6 Ethyl 4-(bromomethyl)benzoate 
• 2393-20-6 3-aminomethylbenzoic acid 
• 157311-42-7 4-tert-butoxycarbonylaminomethylbenzoic acid ethyl ester 

Downstream Products

• 214758-90-4 4-(1-hydroxy-1-methyl-ethyl)benzyl amine 
• 35008-93-6 4-Aminomethyl-benzoesaeurehydrazid 
• 122283-75-4 4-[(5-Cyano-2-methyl-6-methylsulfanyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-methyl]-benzoic acid ethyl ester 
• 109343-18-2 2-[3-(4-Ethoxycarbonyl-benzyl)-thioureido]-5-ethyl-thiophene-3-carboxylic acid ethyl ester 
• 109315-54-0 2-[3-(4-Ethoxycarbonyl-benzyl)-thioureido]-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester 
• 109315-52-8 4-(4-Chloro-phenyl)-2-[3-(4-ethoxycarbonyl-benzyl)-thioureido]-thiophene-3-carboxylic acid ethyl ester 
• 130832-81-4 7-methyl-2-<(4-ethoxycarbonylphenyl)methylamino>-2-ethoxycarbonyl-2H-1,4-benzthiazin-3(4H)-one 
• 152438-44-3 Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone 
• 152438-46-5 Boc-Tra-Tyr(Z)-4-ethoxycarbonylbenzylaminomethyl ketone 
• 102212-36-2 4-[(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylamino)-methyl]-benzoic acid ethyl ester 
• 102212-80-6 4-[5-Hydroxy-1,3-dimethyl-6-(3-methyl-but-2-enyl)-2,4,7-trioxo-1,2,3,4-tetrahydro-7H-1,3,4b,8,9-pentaaza-fluoren-8-ylmethyl]-benzoic acid ethyl ester 
• 109827-30-7 4-[5-(4-Chloro-phenyl)-4-oxo-2-thioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-ylmethyl]-benzoic acid 
• 35009-08-6 C₂₂H₂₁N₅OS₂ 
• 660399-71-3 ethyl 4-{[(4-bromothien-2-yl)carboxamido]methyl}benzoate 

Relevant articles and documents

Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer

Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptosis, which is highly associated with various diseases. In this study, through a stepwise structure optimization, a potent and selective ferroptosis inducer was developed targeting to inhibit glutathione peroxidase 4 (GPX4), and the structure-activity relationship (SAR) of these compounds was uncovered. Compound26aexhibited outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 μM compared to 45.9% of RSL-3. At the cellular level,26acould significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity (the value of 31.5). The morphological analysis confirmed the ferroptosis induced by26a. Furthermore,26asignificantly restrained tumor growth in a mouse 4T1 xenograft model without obvious toxicity.

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P-aminomethyl benzoic acid and preparation method thereof

The invention discloses p-aminomethyl benzoic acid and a preparation method thereof. The method comprises the following steps: hydrolyzing phthalic anhydride as a raw material under an alkaline condition to enable the anhydride structure of phthalic anhydride to be subjected to ring opening to obtain an intermediate 1; performing decarboxylation reaction on the intermediate 1 under the condition that high-temperature liquid water is used as a reaction medium to obtain an intermediate 2; converting original binary acid of the intermediate 1 into monobasic acid, and enabling the intermediate 2 to react with a saturated monochloromethane diethyl ether solution by taking diethyl ether as a solvent under the catalytic action of aluminum chloride to obtain an intermediates 3; and carrying out bromine substitution reaction on the intermediate 3 and N-bromosuccinimide, and carrying out ammoniation reaction under the action of triethylamine and potassium carbonate. The yield of p-aminomethyl benzoic acid prepared by the preparation method of p-aminomethyl benzoic acid is high, and compared with an existing preparation method, most of the used raw materials are low-price raw materials, cyanogroups with high toxicity are not introduced, and the production cost of tranexamic acid is greatly reduced.