367-32-8

Basic information

• Product Name: 4-Fluorocatechol
• Synonyms: 4-FLUOROBENZENE-1,2-DIOL;4-FLUOROCATECHOL;4-Fluoro-1,2-Dihydroxy-Benzene;1,2-Dihydroxy-4-fluorobenzene;4-Fluoro-1,2-benzenediol;4-fluoropyrocatechol;4-Fluorocatechol 97%;4-Fluorocatechol97%
• CAS NO: 367-32-8
• Molecular Formula: C₆H₅FO₂
• Molecular Weight: 128.1
• Product Categories: Phenol&Thiophenol&Mercaptan;Heterocyclic Compounds;Benzenes
• Mol File: 367-32-8.mol
• Article Data: 25

Chemical Properties

• Melting Point: 90-91
• Boiling Point: 258 °C at 760 mmHg
• Flash Point: 109.8 °C
• Appearance: /
• Density: 1.415 g/cm³
• Storage Temp.: 2-8°C
• Solubility: Acetone (Slightly), Methanol (Slightly)
• PKA: 8.80±0.10(Predicted)
• CAS DataBase Reference: 4-Fluorocatechol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorocatechol(367-32-8)
• EPA Substance Registry System: 4-Fluorocatechol(367-32-8)

Safety Data

• Hazard Codes: Xi
• RIDADR: 2923
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 367-32-8(Hazardous Substances Data)

Usage

General Description

4-Fluorocatechol is a chemical compound with the molecular formula C6H5FO2. It is a fluorinated derivative of catechol and is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 4-Fluorocatechol is known for its use as a precursor in the production of synthetic dyes and flaorochromes. It is a white crystalline solid with a melting point of around 77-78 degrees Celsius, and it is soluble in water, methanol, and ethanol. 4-Fluorocatechol is also used in the field of organic synthesis as a reagent in the preparation of certain organic compounds. Its unique properties and versatility make it a valuable chemical in the field of research and development.

InChI:InChI=1/C6H5FO2/c7-4-1-2-5(8)6(9)3-4/h1-3,8-9H

Upstream product

• 398-62-9 4-fluoroveratrole 
• 72955-97-6 5-fluoro-2-methoxy phenol 
• 407-25-0 trifluoroacetic anhydride 
• 446-36-6 5-fluoro-2-nitrophenol 
• 371-41-5 4-Fluorophenol 
• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 
• 1315577-30-0 C₁₄H₂₃FO₂Si 
• 98-29-3 4-tert-Butylcatechol 
• 371-35-7 sodium 4-fluorophenoxide 
• 540-36-3 para-difluorobenzene 
• 450-93-1 2-methoxy-4-fluorophenol 

Downstream Products

• 62834-26-8 5-fluoro-3'-methyl-2-phenoxy-2λ⁵-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidine] 
• 931424-24-7 dimethyl 2,2’-((4-fluoro-1,2-phenylene)bis(oxy))diacetate 
• 656804-73-8 4-bromo-5-fluorobenzene-1 ,2-diol 
• 118070-98-7 4-fluorocyclohexa-3,5-diene-1,2-dione 
• 1260398-02-4 2,2'-(4-fluoro-1,2-phenylene)bisoxydiethanol 
• 1344113-54-7 4-fluorocatechol diacetate 
• 147900-49-0 5-fluorobenzo[d][1,3]dioxolene 
• 1366234-03-8 (6-fluoro-1,3-benzodioxol-5-yl)amine 
• 1448465-06-2 C₁₂H₁₁FO₆ 
• 1450648-53-9 N-((6-fluorobenzo[d][1,3]dioxol-5-yl)carbamothioyl)benzamide 
• 492444-09-4 tert-butyl (5-fluoro-1,3-benzodioxol-4-yl)carbamate 
• 492444-08-3 5-fluoro-1,3-benzodioxole-4-carboxylic acid 
• 492444-04-9 5-fluoro-1,3-benzodioxol-4-amine 
• 1260398-03-5 2,2'-(4-fluoro-1,2-phenylene)bisoxybis(ethane-2,1-diyl)bis(4-methylbenzenesulfonate) 

Relevant articles and documents

Anchimerically Assisted Selective Cleavage of Acid-Labile Aryl Alkyl Ethers by Aluminum Triiodide and N, N-Dimethylformamide Dimethyl Acetal

Aluminum triiodide is harnessed by N,N-dimethylformamide dimethyl acetal (DMF-DMA) for the selective cleavage of ethers via neighboring group participation. Various acid-labile functional groups, including carboxylate, allyl, tert-butyldimethylsilyl (TBS), and tert-butoxycarbonyl (Boc), suffer the conditions intact. The method offers an efficient approach to cleaving catechol monoalkyl ethers and to uncovering phenols from acetal-type protecting groups such as methoxymethyl (MOM), methoxyethoxymethyl (MEM), and tetrahydropyranyl (THP) chemoselectively.

Pyrimidine or pyrazino five-membered heterocyclic compound and applications thereof

The invention discloses a pyrimidine or pyrazino five-membered heterocyclic compound, a pharmaceutically acceptable salt, a hydrate, a prodrug, a stereoisomer or a solvate thereof, and provides a preparation method of the compound, a composition containing the compound, and applications of the compound in preparation of drugs for treating diseases or disorders related to the action mechanism of EED protein and/or PRC2 protein complex.

Pyrimidone compound and application thereof

The invention discloses a pyrimidone compound, pharmaceutically acceptable salt and solvate thereof, and provides a method for preparing the compounds, a composition containing the compounds and medicinal application of the compounds in preparation of medicines for treating diseases or disorders related to EED protein and/or PRC2 protein complex action mechanisms.