367-97-5Relevant articles and documents
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
Aertssen, Sjoerd,Amundsen-Isaksen, Enya,Brinch, Shoshy Alam,Damen, Eddy,Galera-Prat, Albert,Krauss, Stefan,Leenders, Ruben G. G.,Murthy, Sudarshan,Nieczypor, Piotr,Smits, Johannes N.,Sowa, Sven T.,Waaler, Jo,Wegert, Anita,Lehti?, Lari,Nazaré, Marc
, p. 17936 - 17949 (2021/12/17)
Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-ribosylation of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β-catenin and Hippo signaling pathways that are involved in numerous human diseas
Chromium-catalyzed ligand-free amidation of esters with anilines
Chen, Changpeng,Ling, Liang,Luo, Meiming,Zeng, Xiaoming
supporting information, p. 762 - 766 (2021/04/14)
Amides are important structural motifs in pharmaceutical and agrochemical chemistry because of the intriguing biological active properties. We report here the amidation of commercially available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution.
Palladium-Catalyzed Amide Synthesis via Aminocarbonylation of Arylboronic Acids with Nitroarenes
Peng, Jin-Bao,Li, Da,Geng, Hui-Qing,Wu, Xiao-Feng
supporting information, p. 4878 - 4881 (2019/06/17)
A palladium-catalyzed aminocarbonylation of aryl boronic acids with nitroarenes for the synthesis of amides has been developed. A wide range of substrates were well-tolerated and gave the corresponding amides in moderate to good yields. No external oxidant or reductant was needed in this procedure. This procedure provides a redox-economical process for the synthesis of amides.
