369-54-0

Basic information

• Product Name: 1,4-BIS(DIFLUOROMETHYL)BENZENE
• Synonyms: 1,4-BIS(DIFLUOROMETHYL)BENZENE;ALPHA,ALPHA,ALPHA',ALPHA'-TETRAFLUORO-P-XYLENE;P-XYLYLENE ALPHA,ALPHA,ALPHA',ALPHA'-TETRAFLUORIDE;a,a,a',a'-Tetrafluoro-p-xylene;1,4-Bis(difluoromethyl)benzene 99%;1,4-Bis(difluoromethyl)benzene99%;1,4-Bis-(difluoromethyl)benzene,98%;1,4-Bis-(difluoromet
• CAS NO: 369-54-0
• Molecular Formula: C₈H₆F₄
• Molecular Weight: 178.13
• EINECS: 1312995-182-4
• Mol File: 369-54-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 83-84°C 30mm
• Flash Point: 63°C
• Appearance: clear colorless liquid
• Density: 1,312 g/cm3
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: 1.437-1.439
• Storage Temp.: Flammables area
• CAS DataBase Reference: 1,4-BIS(DIFLUOROMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-BIS(DIFLUOROMETHYL)BENZENE(369-54-0)
• EPA Substance Registry System: 1,4-BIS(DIFLUOROMETHYL)BENZENE(369-54-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-10
• Safety Statements: 37/39-26-16
• PackingGroup: III
• Hazardous Substances Data: 369-54-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C7H6F3NS/c8-7(9,10)12-6-3-1-2-5(11)4-6/h1-4H,11H2

Upstream product

• 623-27-8 terephthalaldehyde, 
• 1592-31-0 1,4-bis(dibromomethyl)benzene 
• 7398-82-5 p-bis-(dichloromethyl)benzene 
• 106-42-3 para-xylene 
• 69922-37-8 2,2'-p-phenylene-bis-[1,3]dithiolane 
• 24588-68-9 2,2'-p-phenylene-bis-[1,3]dithiane 
• 589-87-7 1,4-bromoiodobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 

Downstream Products

• 2629-68-7 1,4-bis-(difluorochloromethyl)-benzene 
• 1743-00-6 4-fluoro-β,β-difluorostyrene 
• 651-12-7 α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene 
• 2250-36-4 1-(bromodifluoromethyl)-4-(difluoromethyl)benzene 
• 3345-29-7 1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane 
• 2250-30-8 α,α,α',α'-tetrafluoro-p-xylylene 
• 3200-21-3 α,α'-Bis-(ethylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-22-4 α,α'-Bis-(propylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-23-5 α,α'-Bis-(butylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-26-8 α,α'-Bis-(ethylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-28-0 α,α'-Bis-(propylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-13-3 α,α'-Bis-(butylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 106-42-3 para-xylene 

Relevant articles and documents

Microwave-assisted synthesis of 1,4-bis(difluoromethyl)benzene

A fast, mild, and practical microwave-assisted protocol for synthesis of 1,4-bis(difluoromethyl)benzene from 1,4-bis(dichloromethyl)benzene and KF was developed. The new protocol increased the yield and reduced the reaction time significantly in contrast to the conventional heating procedure. Also, the synergistic effect of a composite phase transfer catalyst was studied.

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

A stable and isolable difluoromethyl zinc reagent has been prepared through the reaction of ICF2H with diethyl zinc and DMPU. This new zinc reagent is a free-flowing solid and can be used in combination with a nickel catalyst to difluoromethylate aryl iodides, bromides, and triflates at room temperature. Such mild conditions for the catalytic difluoromethylation of these substrates are unprecedented.

Efficient synthesis of p-bis-(chlorodifluoromethyl)benzene

Selective, high yield partial fluorination of p-bis-(trichloromethyl)benzene to p-bis-(chlorodifluoromethyl)benzene has been accomplished by warming a slurry of the p-bis-(trichloromethyl)benzene in anhydrous HF which also contains a small quantity of inert solvent, such as 1,2-dichloroethane.