651-12-7

Basic information

• Product Name: 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE
• Synonyms: ALPHA,ALPHA'-DIBROMO-ALPHA,ALPHA,ALPHA',ALPHA'-TETRAFLUORO-P-XYLENE;1,4-BIS(BROMODIFLUOROMETHYL)BENZENE;ALPHA,ALPHA''-DIBROMO-ALPHA,ALPHA,ALPHA'',ALPHA''-TETRAFLUORO-P-XYLENE/NOBR;1,4-bis(bromodifluor
• CAS NO: 651-12-7
• Molecular Formula: C₈H₄Br₂F₄
• Molecular Weight: 335.92
• EINECS: 1312995-182-4
• Mol File: 651-12-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 102-107℃ (25 Torr)
• Flash Point: 96.2±25.9℃
• Appearance: /
• Density: 1.953±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.076mmHg at 25°C
• Refractive Index: 1.4965-1.4971 (589.3 nm 24℃)
• CAS DataBase Reference: 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE(651-12-7)
• EPA Substance Registry System: 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE(651-12-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 651-12-7(Hazardous Substances Data)

Usage

General Description

1,4-Bis(bromodifluoromethyl)benzene is a chemical compound with the molecular formula C8H6Br2F4. It is a white crystalline solid that is insoluble in water. 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE is commonly used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used in the production of electronic materials and polymers. 1,4-Bis(bromodifluoromethyl)benzene is considered to have low toxicity and is not expected to pose significant risks to human health or the environment when used in accordance with proper handling and safety precautions.

InChI:InChI=1/C8H4Br2F4/c9-7(11,12)5-1-2-6(4-3-5)8(10,13)14/h1-4H

Upstream product

• 369-54-0 p-bis(difluoromethyl)benzene 
• 658-18-4 1,4-bis(difluoromethylene)cyclohexane 
• 106-42-3 para-xylene 
• 1592-31-0 1,4-bis(dibromomethyl)benzene 
• 623-27-8 terephthalaldehyde, 
• 2250-36-4 1-(bromodifluoromethyl)-4-(difluoromethyl)benzene 

Downstream Products

• 3200-28-0 α,α'-Bis-(propylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-13-3 α,α'-Bis-(butylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3345-29-7 1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane 
• 3200-26-8 α,α'-Bis-(ethylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-21-3 α,α'-Bis-(ethylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-22-4 α,α'-Bis-(propylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-23-5 α,α'-Bis-(butylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 433-19-2 1,4-bis(trifluoromethyl)benzene 

Relevant articles and documents

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.

Method for production of halogen-containing aromatic compound

This invention relates to a method for the production of an aromatic compound (II) having a (CH2)nCX2Br group (wherein X represents a fluorine or chlorine atom and the X's may be same or different, and n is an integer in the range of 0 to 4) by the reaction of photo-bromination of an aromatic compound (I) having a (CH2)nCX2H group (wherein X and n are as defined above) with a brominating agent, wherein the photo-bromination reaction is carried out while removing hydrogen bromide generated in the reaction system and/or in an atmosphere of a low oxygen content, and a halogen-containing naphthalene compound represented by the following formula (1): wherein Y represents —CF2H, —CF2Br, or —CHO group, Z1and Z2independently represent a halogen atom, and p and q independently are an integer in the range of 0 to 3.

SYNTHESIS OF 1,1,2,2,9,9,10,10-OCTAFLUORO-PARA-CYCLOPHANE

1,1,2,2,9,9,10,10-Octafluoro-para-cyclophane was obtained by the pyrolysis of α,α'-di-bromo-α,α,α',α'-tetrafluoro-p-xylene using argon as the diluent with further trapping of the pyrolysis products in boiling toluene.The pyrolysis zone was filled with a copper packing to bind bromine.An efficient scheme was also developed for the preparation of α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene starting from p-xylene.