3699-67-0 Usage
Description
TRIETHYL 3-PHOSPHONOPROPIONATE is a clear colorless liquid that serves as a versatile reactant in the synthesis of various compounds and has applications in different industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
TRIETHYL 3-PHOSPHONOPROPIONATE is used as a reactant for the synthesis of Sulfonyl hydroxamate derivatives, which are utilized as inhibitors of class II fructosediphosphate aldolase. This application is significant for the development of drugs targeting metabolic disorders and diseases.
TRIETHYL 3-PHOSPHONOPROPIONATE is also used as a reactant for the synthesis of Imidazole glycerol phosphate dehydratase inhibitors. These inhibitors play a crucial role in the development of therapeutic agents for various diseases, including those affecting cellular metabolism.
Furthermore, TRIETHYL 3-PHOSPHONOPROPIONATE is used as a reactant for the synthesis of Competitive N-methyl-D-aspartate (NMDA) antagonists with analgesic activity. These antagonists are essential in the development of pain relief medications and treatments for neurological disorders.
Used in Biochemical Research:
In the field of biochemical research, TRIETHYL 3-PHOSPHONOPROPIONATE is used as a reactant for the synthesis of Farnesyl phosphonate derivatives of phenylalanine. These derivatives are crucial for the inhibition of farnesyl protein transferase, an enzyme involved in the post-translational modification of proteins, which has implications in the development of drugs targeting cancer and other diseases.
Used in Organic Chemistry:
TRIETHYL 3-PHOSPHONOPROPIONATE is utilized as a reactant for condensation reactions with isobutyraldehyde. This application is vital in the synthesis of various organic compounds, contributing to the advancement of organic chemistry and the development of new materials and chemicals with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 3699-67-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,9 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3699-67:
(6*3)+(5*6)+(4*9)+(3*9)+(2*6)+(1*7)=130
130 % 10 = 0
So 3699-67-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H19O5P/c1-4-12-9(10)7-8-15(11,13-5-2)14-6-3/h4-8H2,1-3H3
3699-67-0Relevant articles and documents
The Reaction of Alkyl 3-Alkoxy-2-bromopropanoate with Triethyl Phosphite
Okamoto, Yoshiki,Tone, Tsutomu,Sakurai, Hiroshi
, p. 303 - 304 (1981)
Alkyl 3-alkoxy-2-bromopropanoate reacted with triethyl phosphite to give alkyl 2,3-bis(diethoxyphosphinyl)propanoate as the major product.
Enantioselective synthesis of putative lipiarmycin aglycon related to fidaxomicin/tiacumicin B
Erb, William,Grassot, Jean-Marie,Linder, David,Neuville, Luc,Zhu, Jieping
supporting information, p. 1929 - 1932 (2015/02/19)
An enantioselective synthesis of a putative lipiarmycin aglycon was accomplished and features: 1) Brown's enantioselective alkoxyallylboration and allylation of aldehydes, 2) chain elongation by iterative Horner-Wadsworth-Emmons olefination, 3) Evans' aldol reaction and 4) an enediene ring-closing metathesis. A neighboring-group-assisted chemoselective reductive desilylation was uncovered in this study and was instrumental to the realization of the present synthesis.
Synthesis of optically-active phosphono analogs of succinates
-
, (2008/06/13)
The present invention relates to catalytic asymmetric hydrogenation of phosphorus analogs of itaconic acid to synthesize novel optically active phosphono succinates.
