37009-52-2

Basic information

• Product Name: ETHYL 2,4-DIPHENYLIMIDAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 2,4-DIPHENYLIMIDAZOLE-5-CARBOXYLATE;ethyl2,5-diphenyl-3H-imidazole-4-carboxylate
• CAS NO: 37009-52-2
• Molecular Formula: C₁₈H₁₆N₂O₂
• Molecular Weight: 292.33184
• Mol File: 37009-52-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2,4-DIPHENYLIMIDAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DIPHENYLIMIDAZOLE-5-CARBOXYLATE(37009-52-2)
• EPA Substance Registry System: ETHYL 2,4-DIPHENYLIMIDAZOLE-5-CARBOXYLATE(37009-52-2)

Safety Data

• Hazardous Substances Data: 37009-52-2(Hazardous Substances Data)

Usage

General Description

Ethyl 2,4-diphenylimidazole-5-carboxylate is a chemical compound with the molecular formula C18H15N3O2. It is a derivative of imidazole and is commonly used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. ETHYL 2,4-DIPHENYLIMIDAZOLE-5-CARBOXYLATE has been found to exhibit antimicrobial, antifungal, and antitumor activities in scientific research, making it a valuable tool for drug discovery and development. Additionally, ethyl 2,4-diphenylimidazole-5-carboxylate has shown potential as a fluorescent probe for the detection of metal ions in biological and environmental systems, further expanding its range of applications in various fields of chemistry and biology.

Upstream product

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• 29670-63-1 N-benzoyl-2-phenylglycine 
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• 61013-61-4 ethyl 2-azido-3-phenylacrylate 
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• 40780-81-2 S-methyl thioimidate of benzoic acid 

Downstream Products

• 857271-71-7 ethyl 1-methyl-2,4-diphenyl-1H-imidazole-5-carboxylate 
• 15994-88-4 1-methyl-2,5-diphenyl-1H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

2, 5-substituent-1H-imidazole-4-carboxylic ester compound and synthesis and purification method thereof

The invention provides a 2, 5-substituent-1H-imidazole-4-carboxylic ester compound and a synthesis and purification method thereof, the method uses iodine as an oxidizing agent to promote the oxidative cyclization reaction of an enamine compound, so that the operation of preparing the 2, 5-substituent-1H-imidazole-4-carboxylic ester compound is simpler, the preparation cost is greatly reduced, the relative yield and purity are higher, and the environmental pollution is less. Besides, the 2, 5-substituent-1H-imidazole-4-carboxylic ester compound provided by the invention has been widely applied in the fields of medicine, ligand chemistry and material science due to the special heterocyclic skeleton, and is a valuable synthetic intermediate and a functional organic molecule.

Synthesis of polyfunctional imidazoles from vinyl azides and amidine along with NHBoc as a leaving group

An efficient method for the synthesis of polyfunctional imidazoles from vinyl azides and amidine has been developed. Starting from vinyl azide and amidine, this transformation proceeds without any additives and the obtained imidazoles can be decorated with ester functional group that is a promising site for further modification.

A Domino Azidation/C-H Amination Approach toward Trifluoromethyl Substituted Imidazoles

N-Alkyl enamines can be transformed into 2,4,5-trisubsituted imidazoles by reacting with (diacetoxyiodo)benzene and TMSN3 under the catalysis of a copper salt such as Cu(OAc)2. Tetrabutyl ammonium iodide was also capable of promoting the reaction. The transformation from N-alkyl enamines into 2,4,5-trisubsituted imidazoles took place in a domino azidation/intramolecular C(sp3)-H amination pattern. The present reaction provides a new efficient method for the preparation of 4-(trifluoromethyl) imidazoles.