370851-82-4

Basic information

• Product Name: Benzenesulfonamide, N-[2-(4-bromobenzoyl)phenyl]-4-methyl-
• CAS NO: 370851-82-4
• Molecular Formula: C20H16BrNO3S
• Molecular Weight: 430.322
• Mol File: 370851-82-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[2-(4-bromobenzoyl)phenyl]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[2-(4-bromobenzoyl)phenyl]-4-methyl-(370851-82-4)
• EPA Substance Registry System: Benzenesulfonamide, N-[2-(4-bromobenzoyl)phenyl]-4-methyl-(370851-82-4)

Safety Data

• Hazardous Substances Data: 370851-82-4(Hazardous Substances Data)

Upstream product

• 1140-17-6 2-amino-4'-bromobenzophenone 
• 98-59-9 p-toluenesulfonyl chloride 
• 118-92-3 anthranilic acid 
• 941-55-9 4-toluenesulfonyl azide 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 108-86-1 bromobenzene 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 

Downstream Products

• 1238251-85-8 N-(2-(1-(4-bromophenyl)-1-hydroxy-3-phenylprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide 
• 1261245-28-6 N-(2-(1-(4-bromophenyl)-1-hydroxybut-3-enyl)phenyl)-4-methylbenzenesulfonamide 
• 1448808-83-0 3-(4-bromophenyl)-3-(diiodomethyl)-1-tosylindolin-2-one 
• 1351557-17-9 11-(4-bromophenyl)-6-methyl-6H-indolo[2,3-b]quinoline 
• 1315477-47-4 1-(4-bromophenyl)-1-(2-(tosylamino)phenyl)prop-2-yn-1-ol 
• 1315477-66-7 3-(4-bromophenyl)-1-tosyl-1H-indole-2-carbaldehyde 
• 1334483-34-9 5-(4-bromophenyl)-1-tosyl-2,3-dihydro-1H-benzo[b]azepine 
• 1334483-25-8 1-cyclopropyl-1-(2-(tosylamino)phenyl)(4-bromophenyl)methanol 
• 1291080-09-5 4-(4-bromophenyl)-3-iodo-2-phenylquinoline 
• 500870-80-4 2-N-(4-aminosulfonylbenzoyl)-amide-4'-bromo-benzophenone 
• 500870-79-1 2-N-(4-methylsulfonylbenzoyl)-amide-4'-bromo-benzophenone 
• 374606-77-6 4-[3-(4-bromophenyl)-1-(4-methylphenylsulfonyl)-1H-2-indolyl]-2-butanone 
• 374541-52-3 2-[4-bromophenyl(5-methyl-2-furyl)methyl]-1-(4-methylphenylsulfonamido)benzene 
• 373618-56-5 2-[4-bromophenyl(hydroxy)methyl]-1-(4-methylphenylsulfonamido)benzene 

Relevant articles and documents

Ru(ii)-catalyzed intermolecular ortho-C-H amidation of aromatic ketones with sulfonyl azides

Ru(ii)-catalyzed intermolecular ortho-C-H amidation of weakly coordinating aromatic ketones with sulfonyl azides is reported. The developed reaction protocol can be extended to various substituted aromatic ketones to afford a wide range of desired C-N bond formation products in good yields.

Silver acetate catalyzed hydroamination of 1-(2-(sulfonylamino)phenyl)prop- 2-yn-1-ols to (Z)-2-methylene-1-sulfonylindolin-3-ols

A method to prepare (Z)-2-methylene-1-sulfonylindolin-3-ols efficiently that relies on silver acetate catalyzed hydroamination of 1-(2-(sulfonylamino) phenyl)prop-2-yn-1-ols is reported. The reactions proceed rapidly at room temperature with catalyst loadings as low as 1 mol % under conditions that did not require the exclusion of air or moisture. The utility of this N-heterocyclic ring-forming strategy as a synthetic tool that makes use of unsaturated alcohols was exemplified by the conversion of the (Z)-2-methylene-1- sulfonylindolin-3-ol to examples of other members of the indole family of compounds.

Cyclopropyl carbinol rearrangement for benzo-fused nitrogen ring synthesis

A synthetic method that relies on gold-catalysed cyclopropyl carbinol rearrangement of 2-tosylaminophenyl cyclopropylmethanols to prepare 2,3-dihydro-1H-benzo[b]azepines and 2-vinylindolines efficiently is reported. The reactions were shown to be chemoselective, with secondary and tertiary alcohol substrates exclusively providing benzo-fused five- and seven-membered ring products, respectively. The ring-forming process was also found to proceed in moderate to excellent yields under mild conditions only in the presence of the gold and silver catalyst combination. The mechanism is thought to involve activation of the alcohol by the (p-CF3C6H 4)3PAuCl/AgOTf (Tf=triflate) catalyst, resulting in ionization of the starting material. The tertiary carbocationic intermediate generated in situ in this manner then triggers ring-opening of the cyclopropane moiety and trapping by the tethered aniline group to give the 2,3-dihydro-1H-benzo[b]azepine. Cyclopropane ring fragmentation of the secondary carbocationic analogue, on the other hand, results in diene formation followed by subsequent intramolecular hydroamination to afford the 2-vinylindoline. Copyright