371111-51-2Relevant articles and documents
Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design
Venkatraman, Srikanth,Njoroge, F. George,Girijavallabhan, Viyyoor M.,Madison, Vincent S.,Yao, Nanua H.,Prongay, Andrew J.,Butkiewicz, Nancy,Pichardo, John
, p. 5088 - 5091 (2007/10/03)
Hepatitus C virus (HCV) NS3, when bound to NS4A cofactor, facilitates development of mature virons by catalyzing cleavage of a polyprotein to form functional and structural proteins of HCV. The enzyme has a shallow binding pocket at the catalytic site, ma
Application of ruthenium induced cyclization for construction of strained biaryl ether macrocyclic compounds
Venkatraman, Srikanth,George Njoroge,Girijavallabhan, Viyyoor
, p. 5453 - 5458 (2007/10/03)
Synthesis of strained macrocyclic biaryl ethers of type 1 and 2 were accomplished using η6-ruthenium-induced macroetherification. This novel application demonstrates the versatility of this method in construction of constrained macrocyclic biar