371110-93-9Relevant articles and documents
Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design
Venkatraman, Srikanth,Njoroge, F. George,Girijavallabhan, Viyyoor M.,Madison, Vincent S.,Yao, Nanua H.,Prongay, Andrew J.,Butkiewicz, Nancy,Pichardo, John
, p. 5088 - 5091 (2007/10/03)
Hepatitus C virus (HCV) NS3, when bound to NS4A cofactor, facilitates development of mature virons by catalyzing cleavage of a polyprotein to form functional and structural proteins of HCV. The enzyme has a shallow binding pocket at the catalytic site, ma